64620-30-0

Basic information

• Product Name: 2(3H)-Furanone, 3-[1-[(4-chlorophenyl)amino]ethylidene]dihydro-, (Z)-
• CAS NO: 64620-30-0
• Molecular Formula: C12H12ClNO2
• Molecular Weight: 237.686
• Mol File: 64620-30-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2(3H)-Furanone, 3-[1-[(4-chlorophenyl)amino]ethylidene]dihydro-, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(3H)-Furanone, 3-[1-[(4-chlorophenyl)amino]ethylidene]dihydro-, (Z)-(64620-30-0)
• EPA Substance Registry System: 2(3H)-Furanone, 3-[1-[(4-chlorophenyl)amino]ethylidene]dihydro-, (Z)-(64620-30-0)

Safety Data

• Hazardous Substances Data: 64620-30-0(Hazardous Substances Data)

Upstream product

• 517-23-7 3-acetyl-2-oxo-4,5-dihydrofuran 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 57521-14-9 4,6-dichloro-3-(2-chloro-ethyl)-2-methyl-quinoline 
• 200932-38-3 8-Chloro-1-(4-fluoro-phenyl)-4-methyl-2,3-dihydro-1H-pyrrolo[3,2-c]quinoline 

Relevant articles and documents

Enamination of β-dicarbonyl compounds with amines

Enamination of a wide variety of primary amines was successfully described with excellent chemoselectivity in the presence of catalytic amounts of β-cyclodextrin in water under mild conditions. Aliphatic amines also reacted efficiently to produce the corresponding enaminones.

Cerium(III) chloride heptahydrate (CeCl3·7H2O) as an efficient enamination catalyst in aqueous media

Cerium(III) chloride heptahydrate CeCl3·H2O catalyzes enamination of β-dicarbonyl compounds with primary amines in aqueous medium at room temperature to afford the corresponding β-enamino ketones with high chemoselectivity.

Potential antineoplastics. Synthesis and cytotoxicity of certain 4- chloro-3-(2-chloroethyl)-2-methylquinolines and related derivatives

In an extension of our work in the held of nitrogen heterocycles with potential cytotoxic activity, the synthesis of some substituted 4-chloro-3- (2-chloroethyl)-2-methylquinolines (10-13) from their parent 3-[l- (phenylamino)ethylidene]-dihydro-2(3H)-furanones (6-9) is reported. The conversion of 10-13 to some thieno-, furo- and pyrrolo[3,2-c]quinolines (14- 27, 31-33) is also described. The compounds were evaluated for their toxicity in brine shrimp (Artemia salina), and their cytotoxicity against some clinically isolated human tumors in vitro. Several compounds exhibited good toxic activity against Artemia salina, while the furanone (6, NSC 680781) displayed good antineoplastic activity and high selectivity against some cell lines from leukemia, lung cancer, colon and melanoma panels. This compound has been selected by the NCI for further testing in a new in vivo anticancer hollow fiber assay.