64887-40-7

Basic information

• Product Name: 3-(2-BENZOXAZOLYL)-7-HYDROXYCOUMARIN
• Synonyms: 3-(2-BENZOXAZOLYL)UMBELLIFERONE;3-(2-BENZOXAZOLYL)-7-HYDROXYCOUMARIN;3-benzoxazol-2-yl-7-hydroxy-1-benzopyran-2(2H)-one;3-(2-BENZOXAZOLYL)UMBELLIFERONE, FOR FLU ORESCENCE;3-(2-Benzolyl)-7-hydroxycoumarin;3-(Benzoxazol-2-yl)-7-hydroxy-2H-1-benzopyran-2-one;7-Hydroxy-3-(benzoxazole-2-yl)-2H-1-benzopyran-2-one;3-(benzo[d]oxazol-2-yl)-7-hydroxy-2H-chromen-2-one
• CAS NO: 64887-40-7
• Molecular Formula: C₁₆H₉NO₄
• Molecular Weight: 279.25
• EINECS: 265-263-8
• Mol File: 64887-40-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 302 °C(lit.)
• Boiling Point: 550.558°C at 760 mmHg
• Flash Point: 286.767°C
• Appearance: /
• Density: 1.487g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.722
• Solubility: DMF: soluble
• CAS DataBase Reference: 3-(2-BENZOXAZOLYL)-7-HYDROXYCOUMARIN(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-BENZOXAZOLYL)-7-HYDROXYCOUMARIN(64887-40-7)
• EPA Substance Registry System: 3-(2-BENZOXAZOLYL)-7-HYDROXYCOUMARIN(64887-40-7)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 8
• Hazardous Substances Data: 64887-40-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H9NO4/c18-10-6-5-9-7-11(16(19)21-14(9)8-10)15-17-12-3-1-2-4-13(12)20-15/h1-8,18H

Upstream product

• 39116-38-6 2-benzooxazol-2-yl-3-oxo-propionitrile 
• 108-46-3 recorcinol 
• 16105-44-5 benzooxazol-2-yl-acetic acid ethyl ester 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 15344-56-6 2-(benzo[d]oxazol-2-yl)acetonitrile 
• 105-56-6 ethyl 2-cyanoacetate 
• 95-55-6 2-amino-phenol 

Downstream Products

• 97004-78-9 7-acetoxy-3-(2-benzoxazolyl)coumarin 
• 97004-80-3 Octanoic acid 3-benzooxazol-2-yl-2-oxo-2H-chromen-7-yl ester 
• 94105-99-4 Phosphoric acid mono-(3-benzooxazol-2-yl-2-oxo-2H-chromen-7-yl) ester; compound with pyridine 

Relevant articles and documents

Glycerol and acetic acid assisted mild strategy for facile synthesis of 3-heteroarylcoumarins via three-component reaction

A feasible and inexpensive reaction system for synthesis of 3-benzoxazol-2-yl-chromen-2-one as a kind of 3-heteroarylcoumarins has been developed. Both acetic acid and glycerol are simple, cheap and common chemicals, the combination of them could smoothly accelerate the three-component one-pot reaction of salicylaldehyde, o-aminophenol and ethyl cyanoacetate to yield 3-heteroarylcoumarins. This process not only offers the products in good to excellent yields but also avoids the problems associated with catalyst cost, handling, safety and pollution. Compared with the literature, the reaction temperature successfully reduced to 80?°C. As an application, disperse yellow 232 was furnished with a satisfactory yield under optimum reaction conditions. In addition, all synthesized 3-heteroarylcoumarins were preliminary evaluated the inhibitory effect against human carboxylesterase 1. This protocol offers an expedient strategy for efficient synthesis of 3-heteroarylcoumarins that are widely present in biologically active compounds and fluorescent paints.

Compounds for treating spinal muscular atrophy

Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.

Synthesis of Some Coumarin Derivatives as Potential Laser Dyes

With a view to extend the tunability range and maximum output of the coumarin series of dyes, fifteen new 3-substituted 7-hydroxycoumarins emitting in the blue-green region of the visible spectrum are synthesized, and some of them showed laser activity.