65031-95-0 Usage
General Description
S-Glycidyl acetate is a chemical compound with the molecular formula C6H10O3. It is a highly reactive compound that is commonly used in the production of adhesives, coatings, and resins. It is also utilized as a precursor in the synthesis of various polymers and pharmaceuticals. S-Glycidyl acetate is classified as an epoxide, which means it contains a three-membered ring consisting of one oxygen atom and two carbon atoms. This structure gives it the ability to undergo ring-opening reactions, making it a versatile building block in organic synthesis. However, S-Glycidyl acetate is also considered a hazardous chemical, as it can cause skin and eye irritation, as well as respiratory issues if inhaled. Therefore, proper safety precautions should be taken when handling and working with this compound.
Check Digit Verification of cas no
The CAS Registry Mumber 65031-95-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,0,3 and 1 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 65031-95:
(7*6)+(6*5)+(5*0)+(4*3)+(3*1)+(2*9)+(1*5)=110
110 % 10 = 0
So 65031-95-0 is a valid CAS Registry Number.
InChI:InChI=1/C5H8O3/c1-4(6)7-2-5-3-8-5/h5H,2-3H2,1H3/t5-/m1/s1
65031-95-0Relevant articles and documents
Continuous-Flow Synthesis of (R)-Propylene Carbonate: An Important Intermediate in the Synthesis of Tenofovir
Suveges, Nicolas S.,Rodriguez, Anderson A.,Diederichs, Carla C.,de Souza, Stefania P.,Le?o, Raquel A. C.,Miranda, Leandro S. M.,Horta, Bruno A. C.,Pedraza, Sérgio F.,de Carvalho, Otavio V.,Pais, Karla C.,Terra, José H. C.,de Souza, Rodrigo O. M. A.
supporting information, p. 2931 - 2938 (2018/06/27)
(R)-Propylene carbonate is an important intermediate in the synthesis of tenofovir pro-drugs such as tenofovir alafenamide fumarate (TAF) and tenofovir diisoproyl fumarate (TDF). Independent of the pro-drug type, tenofovir presents a chiral secondary hydroxy derivative, which can be obtained directly from (R)-propylene carbonate. Herein, we report our chemo-enzymatic continuous-flow strategy towards (R)-propylene carbonate starting from a very cheap and renewable raw material, glycerol. We were able to synthesize (R)-propylene carbonate in seven continuous-flow steps, starting from glycerol, in good-to-excellent yields (66–93 %) and excellent selectivity (E > 200).
