65095-13-8

Basic information

• Product Name: BENZOTRIAZOLE-1-CARBONYL CHLORIDE TECH.
• Synonyms: BENZOTRIAZOLE-1-CARBONYL CHLORIDE TECH.;1H-Benzotriazole-1-carbonyl chloride (9CI);1-Chlorocarbonylbenzotriazole;1H-Benzotriazole-1-carbonyl chloride
• CAS NO: 65095-13-8
• Molecular Formula: C₇H₄ClN₃O
• Molecular Weight: 181.57916
• Product Categories: ACIDHALIDE;C-C Bond Formation;Others;Synthetic Reagents
• Mol File: 65095-13-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 51-55 °C(lit.)
• Boiling Point: 335.9°C at 760 mmHg
• Flash Point: >230 °F
• Appearance: /
• Density: 1.57 g/cm³
• Vapor Pressure: 0.000116mmHg at 25°C
• Refractive Index: 1.716
• CAS DataBase Reference: BENZOTRIAZOLE-1-CARBONYL CHLORIDE TECH.(CAS DataBase Reference)
• NIST Chemistry Reference: BENZOTRIAZOLE-1-CARBONYL CHLORIDE TECH.(65095-13-8)
• EPA Substance Registry System: BENZOTRIAZOLE-1-CARBONYL CHLORIDE TECH.(65095-13-8)

Safety Data

• Hazard Codes: C
• Statements: 22-34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3131 4.3/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 65095-13-8(Hazardous Substances Data)

Usage

Description

BENZOTRIAZOLE-1-CARBONYL CHLORIDE TECH., also known as BTC, is a water-insoluble and highly reactive chemical compound used in the production of pharmaceuticals, agrochemicals, and dyes. It is commonly utilized as an acylating agent in organic synthesis due to its ability to react with a variety of compounds, including amines, alcohols, and thiols, making it a versatile reagent in chemical manufacturing.
Used in Pharmaceutical Industry:
BENZOTRIAZOLE-1-CARBONYL CHLORIDE TECH. is used as an acylating agent for the synthesis of various pharmaceutical compounds. Its versatility in reacting with different types of compounds allows for the creation of a wide range of drug molecules.
Used in Agrochemical Industry:
In the agrochemical industry, BENZOTRIAZOLE-1-CARBONYL CHLORIDE TECH. is used as a key intermediate in the production of various agrochemicals. Its reactivity and ability to form stable bonds with other compounds make it an essential component in the synthesis of effective and stable agrochemical products.
Used in Dye Industry:
BENZOTRIAZOLE-1-CARBONYL CHLORIDE TECH. is used as a building block in the production of dyes. Its reactivity and compatibility with other chemical compounds enable the creation of a diverse range of dyes with different properties and applications.
It is important to handle BENZOTRIAZOLE-1-CARBONYL CHLORIDE TECH. with care, as it can be irritant to the skin, eyes, and respiratory system. Proper safety measures should be taken during its use to minimize potential health risks.

InChI:InChI=1/C7H4ClN3O/c8-7(12)11-6-4-2-1-3-5(6)9-10-11/h1-4H

Upstream product

• 95-14-7 1,2,3-Benzotriazole 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 75-44-5 phosgene 

Downstream Products

• 189566-60-7 Benzotriazole-1-carboxylic acid 4-methoxy-benzyl ester 
• 130384-98-4 tert-butyl 1H-benzo[d][1,2,3]triazole-1-carboxylate 
• 230644-97-0 1-(1H-benzo[d][1,2,3]triazol-1-yl)-2-(4-isobutylphenyl)propan-1-one 
• 1149724-09-3 1-(1H-benzo[d][1,2,3]triazol-1-yl)-2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]ethan-1-one 
• 1428369-91-8 C₁₅H₁₄N₆O₂ 
• 1428369-92-9 C₁₆H₁₆N₆O₂ 
• 1428369-93-0 1-(1-benzotriazolecarbonyl)-4-benzhydrylsemicarbazide 
• 301651-11-6 N-benzyloxy-1H-benzotriazole-1-carboxamide 
• 1445852-06-1 C₁₄H₁₈N₆O₂ 
• 1218923-24-0 2-(3-(N-benzotriazolcarbonyloxy)(phenyl)(methyl)phenyl) propanoic acid benzotriazolide 
• 1218923-23-9 2-(3-(hydroxy(phenyl)methyl)phenyl)propanoic acid benzotriazolide 
• 934701-74-3 C₁₅H₁₄N₄O 
• 845786-72-3 N-(1-benzotriazolecarbonyl)-D-phenylglycine cyclohexanemethylamide 
• 845786-74-5 N-(1-benzotriazolecarbonyl)-D-phenylglycine diphenylmethylamide 

Relevant articles and documents

Discovery of a Potent, Long-Acting, and CNS-Active Inhibitor (BIA 10-2474) of Fatty Acid Amide Hydrolase

Fatty acid amide hydrolase (FAAH) can be targeted for the treatment of pain associated with various medical conditions. Herein we report the design and synthesis of a novel series of heterocyclic-N-carboxamide FAAH inhibitors that have a good alignment of potency, metabolic stability and selectivity for FAAH over monoacylglycerol lipase (MAGL) and carboxylesterases (CEs). Lead optimization efforts carried out with benzotriazolyl- and imidazolyl-N-carboxamide series led to the discovery of clinical candidate 8 l (3-(1-(cyclohexyl(methyl)carbamoyl)-1H-imidazol-4-yl)pyridine 1-oxide; BIA 10-2474) as a potent and long-acting inhibitor of FAAH. However, during a Phase I clinical trial with compound 8 l, unexpected and unpredictable serious neurological adverse events occurred, affecting five healthy volunteers, including the death of one subject.

Novel NSAID 1-acyl-4-cycloalkyl/arylsemicarbazides and 1-acyl-5-benzyloxy/ hydroxy carbamoylcarbazides as potential anticancer agents and antioxidants

The novel 1-acyl-4-cycloalkyl/arylsemicarbazides (5a-y) and 1-acyl-5-benzyloxy/hydroxycarbamoylcarbazides (8a-f) derived from the nonsteroidal anti-inflammatory drugs ibuprofen, fenoprofen and reduced ketoprofen were prepared, fully chemically characteriz

CARBAMOYLBENZOTRIAZOLE DERIVATIVES AS INHIBITORS OF LIPASES AND PHOSPHOLIPASES

The invention relates to carbamoylbenzotriazole derivatives of general formula (I), which are defined as cited in the description, to their pharmaceutically applicable salts and to their use as medicaments.