651031-01-5
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Basic information
- Product Name: XL-647
- Synonyms: 4-Quinazolinamine, N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-[[(3aa,5a,6aa)-octahydro- 2-met
- CAS NO:651031-01-5
- Molecular Formula: C24H19Cl2FN4O2
- Molecular Weight: 485.35
- EINECS: -0
- Product Categories: N/A
- Mol File: 651031-01-5.mol
- Article Data: 0
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: XL-647(CAS DataBase Reference)
- NIST Chemistry Reference: XL-647(651031-01-5)
- EPA Substance Registry System: XL-647(651031-01-5)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 651031-01-5(Hazardous Substances Data)
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651031-01-5 Usage
Description
XL-647 is a novel spectrum-selective kinase inhibitor that targets various receptors, including EGFR, ErbB2, KDR, Flt-4, and EphB4. It exhibits potent inhibitory activity with low IC50 values, making it a promising compound for pharmaceutical applications.Uses
Used in Pharmaceutical Industry:XL-647 is used as a spectrum-selective kinase inhibitor for targeting multiple receptors such as EGFR, ErbB2, KDR, Flt-4, and EphB4. Its potent inhibitory activity with low IC50 values (0.3 nM, 16 nM, 1.5 nM, 8.7 nM, and 1.4 nM, respectively) makes it a valuable compound in the development of targeted therapies for various diseases, including cancer.
Used in Cancer Treatment:
XL-647 is used as a potent and selective EGFR phosphorylation inhibitor, specifically targeting the EGFR receptor. This selective inhibition can potentially lead to the development of more effective treatments for cancer, as it may help to minimize off-target effects and reduce the risk of side effects associated with non-selective inhibitors.
Check Digit Verification of cas no
The CAS Registry Mumber 651031-01-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,5,1,0,3 and 1 respectively; the second part has 2 digits, 0 and 1 respectively.Calculate Digit Verification of CAS Registry Number 651031-01:
(8*6)+(7*5)+(6*1)+(5*0)+(4*3)+(3*1)+(2*0)+(1*1)=105
105 % 10 = 5
So 651031-01-5 is a valid CAS Registry Number.
InChI:InChI=1S/C24H25Cl2FN4O2/c1-31-9-14-5-13(6-15(14)10-31)11-33-21-8-19-16(7-20(21)32-2)24(29-12-28-19)30-18-4-3-17(25)22(26)23(18)27/h3-4,7-8,12-15H,5-6,9-11H2,1-2H3,(H,28,29,30)/t13?,14-,15+
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651031-01-5Downstream Products
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XL-647
