651053-90-6

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-(2-methylphenyl)-, 1,1-dimethylethyl ester
• CAS NO: 651053-90-6
• Molecular Formula: C17H25NO2
• Molecular Weight: 275.391
• Mol File: 651053-90-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-(2-methylphenyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-(2-methylphenyl)-, 1,1-dimethylethyl ester(651053-90-6)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-(2-methylphenyl)-, 1,1-dimethylethyl ester(651053-90-6)

Safety Data

• Hazardous Substances Data: 651053-90-6(Hazardous Substances Data)

Upstream product

• 16419-60-6 2-Methylphenylboronic acid 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 1028273-34-8 4-o-tolyl-4H-pyridine-1-carboxylic acid tert-butyl ester 
• 110-86-1 pyridine 
• 651053-67-7 4-o-tolyl-4H-pyridine-1-carboxylic acid phenyl ester 
• 932-31-0 ortho-tolylmagnesium bromide 
• 301673-14-3 tert-butyl 4-iodopiperidine-1-carboxylate 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 24424-99-5 di-tert-butyl dicarbonate 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 

Downstream Products

• 630116-52-8 4-(2'-methylphenyl)piperidine 

Relevant articles and documents

Cobalt-Catalyzed Cross-Coupling of 3- and 4-Iodopiperidines with Grignard Reagents

A cobalt-catalyzed cross-coupling between 3- and 4-iodopiperidines and Grignard reagents is disclosed. The reaction is an efficient, cheap, chemoselective, and flexible way to functionalize piperidines. This coupling was used as the key step to realize a short synthesis of (±)-preclamol. Some mechanistic investigations were conducted that highlight the formation of radical intermediates. Scaffold synthesis: A cobalt-catalyzed cross-coupling between iodopiperidines and Grignard reagents is reported (see scheme; PG=protecting group). A large variety of 3- and 4-substituted piperidines were synthesized and the method was applied to a short synthesis of (±)-preclamol. This work constitutes one of the rare examples of cross-couplings involving 3-halogeno piperidines.

Serine derived NK1 antagonists 2: A pharmacophore model for arylsulfonamide binding

Modifications to the spirocyclic aryl sulfonamide portion of serine derived NK1 antagonists allow a partial pharmacophore model to be developed.