6512-32-9Relevant articles and documents
Xylochemical synthesis and biological evaluation of shancigusin c and bletistrin g
Efferth, Thomas,Geske, Leander,Kauhl, Ulrich,Opatz, Till,Saeed, Mohamed E. M.,Schüffler, Anja,Thines, Eckhard
supporting information, (2021/06/16)
The biological activities of shancigusin C (1) and bletistrin G (2), natural products isolated from orchids, are reported along with their first total syntheses. The total synthesis of shancigusin C (1) was conducted by employing the Perkin reaction to forge the central stilbene core, whereas the synthesis of bletistrin G (2) was achieved by the Wittig olefination followed by several regiose-lective aromatic substitution reactions. Both syntheses were completed by applying only renewable starting materials according to the principles of xylochemistry. The cytotoxic properties of shancigusin C (1) and bletistrin G (2) against tumor cells suggest suitability as a starting point for further structural variation.
Identification of N,N-arylalkyl-picolinamide derivatives targeting the RNA-binding protein HuR, by combining biophysical fragment-screening and molecular hybridization
Della Volpe,Linciano,Listro,Tumminelli,Amadio,Bonomo,Elgaher,Adam,Hirsch,Boeckler,Vasile,Rossi,Collina
, (2021/09/06)
Hu proteins are members of the RNA-binding protein (RBP) family and play a pivotal role in the regulation of post-transcriptional processes. Through interaction with selected mRNAs, RBPs regulate their function and stability; as a consequence, RBP dysregu
Stereoselective total synthesis of (-)-curvularin
Jayaprakash, H. V.,Radha Krishna, Muniganti,Sridhar, Gattu,Syed, Tasqeeruddin
supporting information, (2021/12/22)
A concise total synthesis of (-)-Curvularin have been synthesized from commercially available (S)-(?)-propylene epoxide and (3,5-Dimethoxyphenyl)acetic acid. The key steps involved in the synthesis are Vilsmeier-Haack formylation, Grignard reaction, alkyl