65131-08-0

Basic information

• Product Name: 3-phenylsulfonylphthalide
• Synonyms: 3-phenylsulfonylphthalide
• CAS NO: 65131-08-0
• Molecular Weight: 274.297
• Mol File: 65131-08-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-phenylsulfonylphthalide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenylsulfonylphthalide(65131-08-0)
• EPA Substance Registry System: 3-phenylsulfonylphthalide(65131-08-0)

Safety Data

• Hazardous Substances Data: 65131-08-0(Hazardous Substances Data)

Upstream product

• 4122-56-9 methyl o-formylbenzoate 
• 108-98-5 thiophenol 
• 119-67-5 o-carboxybenzaldehyde 
• 16859-59-9 3-hydroxy-1(3H)-isobenzofuranone 
• 51287-54-8 3-(phenylsulfanyl)isobenzofuran-1(3H)-one 

Downstream Products

• 176516-27-1 5,10-dihydroxy-11H-benzo[b]fluoren-11-one 
• 2348-77-8 2-phenyl[1,4]naphthoquinone 
• 60544-07-2 2-(4-methoxyphenyl)naphthalene-1,4-dione 
• 60544-08-3 2-(4-methylphenyl)naphthalene-1,4-dione 
• 59962-62-8 2-(4-chlorophenyl)naphthalene-1,4-dione 
• 65490-97-3 1,2′-binaphthyl-1′,4′-dione 
• 479-11-8 benzo[b]naphtho[2,3-d]furan-6,11-dione 

Relevant articles and documents

Strategies towards potent trypanocidal drugs: Application of Rh-catalyzed [2?+?2?+?2] cycloadditions, sulfonyl phthalide annulation and nitroalkene reactions for the synthesis of substituted quinones and their evaluation against Trypanosoma cruzi

Rhodium-catalyzed [2 + 2 + 2] cycloadditions, sulfonyl phthalide annulations and nitroalkene reactions have been employed for the synthesis of 56 quinone-based compounds. These were evaluated against Trypanosoma cruzi, the parasite that causes Chagas disease. The reactions described here are part of a program that aims to utilize modern, versatile and efficient synthetic methods for the one or two step preparation of trypanocidal compounds. We have identified 9 compounds with potent activity against the parasite; 3 of these were 30-fold more potent than benznidazole (Bz), a drug used for the treatment of Chagas disease. This article provides a comprehensive outline of reactions involving over 120 compounds aimed at the discovery of new quinone-based frameworks with activity against T. cruzi.

Tandem reversible addition-intramolecular lactonization for the synthesis of 3-functionalized phthalides

A new tandem process based on reversible nucleophilic addition and intramolecular lactonization of methyl 2-formylbenzoate leads to the efficient synthesis of 3-functionalized phthalides, which are important precursors for the synthesis of quinone skeletons via Hauser-Kraus annulation. The reactions are successfully carried out under mild conditions in single operations.

Boron Trifluoride Promoted Reaction of Arenesulfinic Acids with Phthalaldehydic Acids: Enroute to 3-Arylsulfonyl Phthalides

The reaction of arenesulfinic acids 4 with phthalaldehydic acids 2 in the presence of boron trifluoride provides a practicable synthetic procedure for the preparation of 3-arylsulfonyl phthalides.