651778-58-4

Basic information

• Product Name: 3-Pyridinecarboxylic acid, 4-(3,5-dimethylphenoxy)-5-ethyl-1,2-dihydro-6-methyl-2-oxo-, ethyl ester
• CAS NO: 651778-58-4
• Molecular Formula: C19H23NO4
• Molecular Weight: 329.396
• Mol File: 651778-58-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarboxylic acid, 4-(3,5-dimethylphenoxy)-5-ethyl-1,2-dihydro-6-methyl-2-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxylic acid, 4-(3,5-dimethylphenoxy)-5-ethyl-1,2-dihydro-6-methyl-2-oxo-, ethyl ester(651778-58-4)
• EPA Substance Registry System: 3-Pyridinecarboxylic acid, 4-(3,5-dimethylphenoxy)-5-ethyl-1,2-dihydro-6-methyl-2-oxo-, ethyl ester(651778-58-4)

Safety Data

• Hazardous Substances Data: 651778-58-4(Hazardous Substances Data)

Upstream product

• 172469-74-8 4-chloro-5-ethyl-6-methyl-3-carbethoxypyridin-2(1H)-one 
• 108-68-9 3,5-Dimethylphenol 
• 90441-39-7 potassium 3,5-dimethylphenoxide 
• 172470-04-1 ethyl 5-ethyl-4-hydroxy-6-methyl-2-oxo-1H-pyridine-3-carboxylate 

Downstream Products

• 651778-60-8 4-(3,5-dimethyl-phenoxy)-5-ethyl-6-methyl-3-nitro-1H-pyridin-2-one 
• 248248-90-0 3-amino-4-(3,5-dimethyl-phenoxy)-5-ethyl-6-methyl-1H-pyridin-2-one 
• 929080-34-2 4-(3,5-dimethyl-phenoxy)-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridine-3-carbaldehyde 
• 929080-41-1 4-(3,5-dimethyl-phenoxy)-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid 
• 929080-31-9 4-(3,5-dimethyl-phenoxy)-5-ethyl-3-hydroxymethyl-6-methyl-1H-pyridin-2-one 
• 651778-59-5 4-(3,5-dimethyl-phenoxy)-5-ethyl-6-methyl-1H-pyridin-2-one 

Relevant articles and documents

Structure-activity relationship in the 3-iodo-4-phenoxypyridinone (IOPY) series: The nature of the C-3 substituent on anti-HIV activity

As part of a systematic SAR study on the 3-iodo-4-phenoxypyridinone 3 (IOPY) type non-nucleoside reverse transcriptase inhibitors, the analogues 4a-4z bearing different C-3 substituents were synthesized and evaluated for their anti-HIV activity against wild-type HIV-1 and four of the principal HIV mutant strains (K103N, Y181C, Y188L, and I100L). The results show that the 3-vinyl analogue 4j is the only compound which displays anti-HIV activity comparable to IOPY 3, and in this respect represents a possible back-up to this lead molecule.