65183-48-4

Basic information

• Product Name: 3,5,7-trimethyl[1,2]oxazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione
• Synonyms: 3,5,7-trimethyl-4,5,6,7-tetrahydroisoxazolo[3,4-d]pyrimidine-4,6-dione
• CAS NO: 65183-48-4
• Molecular Formula: C₈H₉N₃O₃
• Molecular Weight: 195.1754
• Mol File: 65183-48-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 371.4°C at 760 mmHg
• Flash Point: 178.4°C
• Density: 1.358g/cm³
• Vapor Pressure: 1.04E-05mmHg at 25°C
• Refractive Index: 1.551
• CAS DataBase Reference: 3,5,7-trimethyl[1,2]oxazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5,7-trimethyl[1,2]oxazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione(65183-48-4)
• EPA Substance Registry System: 3,5,7-trimethyl[1,2]oxazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione(65183-48-4)

Safety Data

• Hazardous Substances Data: 65183-48-4(Hazardous Substances Data)

Upstream product

• 65183-54-2 3,5-dimethyl-7H-isoxazolo[3,4-d]pyrimidine-4,6-dione 
• 74-88-4 methyl iodide 
• 769-42-6 1,3-dimethylbarbituric acid 
• 32970-32-4 5-acetyl-6-amino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione 
• 123506-39-8 6-hydroxyamino-3-methyluracil 
• 506437-12-3 N-(1,3-dimethyl-6-uracilyl)-S,S-diphenylsulfilimine 
• 6972-27-6 1,3-Dimethyl-6-chlorouracil 
• 506437-21-4 N-(5-acetyl-1,3-dimethyl-6-uracilyl)-S,S-diphenylsulfilimine 
• 61541-41-1 6-azido-1,3-dimethylpyrimidine-2,4(1H,3H)-dione 
• 64-19-7 acetic acid 
• 108-24-7 acetic anhydride 
• 65709-05-9 6-(ethylcarbamoyloxy-amino)-1,3-dimethyl-1H-pyrimidine-2,4-dione 
• 42963-41-7 6-hydroxyamino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione 
• 78-39-7 Triethyl orthoacetate 

Downstream Products

• 1335010-33-7 N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(5,7-dimethyl-4,6-dioxo-4,5,6,7-tetrahydro[1,2]oxazolo[3,4-d]pyrimidin-3-yl)acetamide 

Relevant articles and documents

AMIDES OF HETEROCYCLIC COMPOUNDS AS TRPA1 INHIBITORS

Amides of heterocyclic compounds as Transient Receptor Potential subfamily A (TRPA) modulators are provided In particular, compounds described herein are useful for treating or preventing diseases, conditions and/ or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1) Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1. (I).

Ring closure reactions of β-nitroso-, β-acyl-, and β-thiocarbamoyl-α,β-unsaturated sulfilimines. Synthesis of [1,2,5]oxadiazolo[3,4-d]-, isoxazolo[3,4-d]-, and isothiazolo[3,4-d]pyrimidine derivatives from uracils

1,3-Dialkyl-6-chlorouracils were treated with S,S-diphenylsulfilimine to give N-(1,3-dialkyluracil-6-yl)-S,S-diphenylsulfilimines. The uracilylsulfilimines were nitrosated, acylated, or thiocarbamoylated to give N-(5-nitroso-, 5-acyl-, or 5-thiocarbamoyluracil-6-yl)sulfilimines, respectively. These conjugated sulfilimines were cyclized by thermolysis or photolysis to [1,2,5]oxadiazolo[3,4-d], isoxazolo[3,4-d], or isothiazolo[3,4-d]pyrimidine derivatives.

Pyrimidine Derivatives and Related Compounds. XLVI. Thermal and Photochemical Transformation of 5-Substituted 6-Azido-1,3-dimethyluracils into Fused Pyrimidines such as Isoxazolopyrimidines, Pyrazolo-pyrimidines, and Pyrimido-t

Thermolysis and photolysis of 6-azido-1,3-dimethyluracils possessing certain substituents (formyl, benzoyl, hydrazonomethyl, phenyl, and benzyl groups) at the 5-position provided new methods for the preparation of fused pyrimidines.Irradiation and heating