6522-91-4

Basic information

• Product Name: GUANIDINE, PHENYL-
• CAS NO: 6522-91-4
• Molecular Formula: C₇H₁₀ClN₃
• Molecular Weight: 171.63
• Mol File: 6522-91-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 290.5°Cat760mmHg
• Flash Point: 129.5°C
• Density: 1.17g/cm³
• CAS DataBase Reference: GUANIDINE, PHENYL-(CAS DataBase Reference)
• NIST Chemistry Reference: GUANIDINE, PHENYL-(6522-91-4)
• EPA Substance Registry System: GUANIDINE, PHENYL-(6522-91-4)

Safety Data

• Hazardous Substances Data: 6522-91-4(Hazardous Substances Data)

Upstream product

• 152120-56-4 N,N′-bis(tert-butoxycarbonyl)-N′′-phenylguanidine 
• 62-53-3 aniline 
• 4023-02-3 1H-pyrazole-1-carboximidamide hydrochloride 
• 110235-27-3 4,6-dimethoxy-N-phenylpyrimidin-2-ylamine 
• 108-86-1 bromobenzene 

Downstream Products

• 102-06-7 diphenylguanidine 
• 5199-82-6 N-Chlor-N'-phenyl-guanidin 
• 148363-46-6 1-[4-(4-Fluoro-phenyl)-2-phenylamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-ethanone 
• 2002-16-6 1-phenylguanidine 
• 100185-44-2 1-(3-Ethoxypropionyl)-3-phenylguanidin 
• 100185-43-1 2-Amino-1-phenyl-5,6-dihydro-4(1H)-pyrimidinon 

Relevant articles and documents

Ultrasound-assisted synthesis of substituted guanidines using 1H-pyrazole-1-carboxamidine and S-methylisothiouronium sulfate under solvent-free conditions

We have investigated ultrasound-assisted synthesis of guanidine derivatives using 1H-Pyrazole-1-carboxamidine (PyzCA) and S-substituted isothiouronium sulfate (MeITU). The guanylations of several amines are promoted by ultrasound sonication under solvent-free conditions, and proceed under mild conditions. It is of particular interest that the guanylations do not require bases in most cases.

GUANIDINE BASED COMPOUNDS

The adrenergic receptors or adrenoceptors are a family of G-protein coupled receptors split into α and β subclasses. The adrenoceptors have important roles in regulating a myriad of physiological conditions and their malfunction has been implicated in the pathophysiology of a number of diseases. Disclosed herein are a series of novel guanidine and 2-aminoimidazoline compounds which are ligands of the alpha2-adrenoceptor (α2-ARs) subclass of adrenergic receptors. The invention also provides for pharmaceutical compositions comprising the novel compounds. The compounds are suitable for use in the manufacture of medicaments for the treatment of α2-ARs associated disorders, such as depression, schizophrenia, glaucoma and analgesia.

New cellulose-supported reagent: A sustainable approach to guanidines

(Chemical Equation Presented) A new cellulose-supported reagent for the synthesis of guanidine in aqueous medium is reported starting from commercially available functionalized cellulose beads. Primary and secondary amines, anilines, and amino acids were transformed to the corresponding guanidines in high yields and under very mild conditions.