65235-31-6

Basic information

• Product Name: 4-((2-Hydroxyethyl)amino)-3-nitrophenol
• Synonyms: 4-(2-HYDROXYETHYLAMINO)-3-NITROPHENOL;3-NITRO-4-HYDROXYETHYLAMINOPHENOL;3-NITRO-4-HYDROXYETHYLPHENOL;3-NITRO-N-(BETA-HYDROXYETHYL)-4-AMINOPHENOL;3-NITRO-N-(2-HYDROXYETHYL)-4-AMINOPHENOL;3-NITRO-P-HYDROXYETHYLAMINOPHENOL;JAROCOL NHEAP;HC RED B54
• CAS NO: 65235-31-6
• Molecular Formula: C₈H₁₀N₂O₄
• Molecular Weight: 198.18
• EINECS: 265-648-0
• Product Categories: Aromatic Phenols;Phenol&Thiophenol&Mercaptan
• Mol File: 65235-31-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 142-146℃
• Boiling Point: 446.3 °C at 760 mmHg
• Flash Point: 223.7 °C
• Appearance: dark red crystal powder
• Density: 1.488 g/cm³
• Vapor Pressure: 9.49E-09mmHg at 25°C
• Refractive Index: 1.682
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 9.31±0.14(Predicted)
• CAS DataBase Reference: 4-((2-Hydroxyethyl)amino)-3-nitrophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((2-Hydroxyethyl)amino)-3-nitrophenol(65235-31-6)
• EPA Substance Registry System: 4-((2-Hydroxyethyl)amino)-3-nitrophenol(65235-31-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 65235-31-6(Hazardous Substances Data)

Usage

Contact allergens

This dye belongs to the aminophenol class and is used as a hair colorant, particularly in semipermanent hair dye preparations.

InChI:InChI=1/C8H10N2O4/c11-4-3-9-7-2-1-6(12)5-8(7)10(13)14/h1-2,5,9,11-12H,3-4H2

Synthetic route

2-nitro-N-hydroxyethyl-p-anisidine (57524-53-5) → 4-[(2'-hydroxyethyl)amino]-3-nitrophenol (65235-31-6)

Conditions	Yield
With hydrogen bromide Reflux;	93%

Upstream product

• 57524-53-5 2-nitro-N-hydroxyethyl-p-anisidine 

Downstream Products

• 81612-54-6 3-nitro-4-[N-(β-hydroxyethyl)-amino]-phenyl β,γ-dihydroxypropyl ether 
• 85765-49-7 3-nitro-4-N-(β-hydroxyethyl)-aminophenyl β-hydroxypropyl ether 
• 285567-51-3 2-(4-benzyloxy-2-nitrophenylamino)ethanol 

Relevant articles and documents

Synthesis method of 3-nitro-4-hydroxyethylaminophenol

The invention relates to a synthesis method of 3-nitro-4-hydroxyethylaminophenol. The method comprises the following steps: reacting a compound shown as a formula I with ethanolamine under a heating condition to obtain a compound shown as formula II; and (2) heating the compound II obtained in the step (1) and hydrobromic acid to a reflux condition, carrying out demethylation reaction to obtain acompound 3-nitro-4-hydroxyethylaminophenol hydrobromide, and carrying out reaction on the compound 3-nitro-4-hydroxyethylaminophenol hydrobromide and concentrated ammonia water to obtain a compound shown as formula III, i.e. a target product. The invention provides a brand-new reaction route, cheap and easily available 4-dimethoxy-2-nitrobenzene and ethanolamine are used as the main raw materials,the whole preparation process is simple, easy to operate and free of high toxicity and high risk, the yield of the obtained product is high, and industrial production is easy to realize; and the rawmaterials ethanolamine and hydrobromic acid in the reaction process can both be recycled, thereby reducing three wastes and saving the cost.