65340-70-7

Basic information

• Product Name: 6-BROMO-4-CHLOROQUINOLINE
• Synonyms: BUTTPARK 23\09-04;4-CHLORO-6-BROMOQUINOLINE;6-BROMO-4-CHLOROQUINOLINE;6-Bromo-4-chloroquinoline ,97%;6-Bromo-4-chloroquinoline ,98%;6-Bromo-4-chloro-1-azanaphthalene;4--6-broMinechlorinequinoline;Quinoline,6-bromo-4-chloro-
• CAS NO: 65340-70-7
• Molecular Formula: C₉H₅BrClN
• Molecular Weight: 242.5
• EINECS: -0
• Mol File: 65340-70-7.mol
• Article Data: 20

Chemical Properties

• Melting Point: 110-112℃
• Boiling Point: 314.584 °C at 760 mmHg
• Flash Point: 144.056 °C
• Appearance: /
• Density: 1.673 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.68
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Toluene
• PKA: 2.76±0.16(Predicted)
• CAS DataBase Reference: 6-BROMO-4-CHLOROQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-4-CHLOROQUINOLINE(65340-70-7)
• EPA Substance Registry System: 6-BROMO-4-CHLOROQUINOLINE(65340-70-7)

Safety Data

• Hazard Codes: T
• Statements: 25-20/22
• Safety Statements: 45-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 65340-70-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H5BrClN/c10-6-1-2-9-7(5-6)8(11)3-4-12-9/h1-5H

Upstream product

• 145369-94-4 6-bromoquinolin-4-ol 
• 29124-64-9 N-(2-acetyl-4-bromophenyl)acetamide 
• 68-12-2 N,N-dimethyl-formamide 
• 98948-95-9 6-bromo-4-hydroxyquinoline-3-carboxylic acid 
• 1320361-74-7 ethyl 3-(4-bromoanilino)propenoate 
• 98948-95-9 6-bromo-1,4-dihydro-4-oxo-3-quinoline carboxylic acid 
• 79607-23-1 ethyl 6-bromo-4-oxo-1,4-dihydro-quinoline-3-carboxylate 
• 19056-84-9 diethyl 2-[(p-tolylamino)methylidene]malonate 
• 187278-01-9 5-(((4-bromophenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 145369-94-4 6-bromo-3-quinolinecarboxylic acid-4-ol 
• 106-40-1 4-bromo-aniline 
• 101937-44-4 diethyl 2-((4-bromophenylamino)methylene)malonate 
• 122794-99-4 6-bromo-4-hydroxyquinoline-3-carboxylic acid ethyl ester 

Downstream Products

• 878276-92-7 4-chloro-6-(4-chlorophenyl)quinoline 
• 500127-41-3 4-chloro-6-(4-methoxyphenyl)quinoline 
• 1085443-95-3 3-((6-bromoquinolin-4-yl)amino)phenol 
• 1085526-24-4 4-chloro-6-{[methyl(oxido)phenyl-λ4-sulphanylidene]amino}quinoline 
• 1201841-63-5 N-(2-chloro-5-(4-chloroquinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1201843-85-7 N-(2-chloro-5-(4-(dimethylamino)quinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1201843-87-9 N-(2-chloro-5-(4-(2-methoxyethylamino)quinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1201841-60-2 N-(2-chloro-5-(4-morpholinoquinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1201843-67-5 N-(2-chloro-5-(4-(4-(pyridin-4-ylmethyl)piperazin-1-yl)quinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1201842-11-6 N-(2-chloro-5-(4-(piperidin-1-yl)quinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1201842-17-2 N-(2-chloro-5-(4-(4-hydroxypiperidin-1-yl)quinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1201842-13-8 N-(2-chloro-5-(4-(4-isopropylpiperazin-1-yl)quinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1201842-19-4 N-(5-4-((4-benzylpiperiazin-1-yl)quinolin-6-yl)-2-chloropyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1201842-37-6 N-(2-chloro-5-(4-phenylquinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 

Relevant articles and documents

QUINOLINE-BASED COMPOUNDS AND METHODS OF INHIBITING CDK8/19

Disclosed herein are quinoline-based compounds and method for inhibiting CDK8 or CDK19 for the intervention in diseases, disorders, and conditions. The quinoline-based composition comprise substituents at quinoline ring positions 4 and 6, wherein the substituent at position 4 is selected from a substituted or unsubstituted arylalkylamine or a substituted or unsubstituted arylhetrocyclylamine. Pharmaceutical compositions comprising the substituted qunioline compositions, methods of inhibiting CDK8 or CDK19, and methods of treating CDK8/19-associated diseases, disorders, or conditions are also disclosed.

PI3 kinase modulators and methods of use thereof, and use thereof

The invention belongs to the field of medicines, concretely relates to a compound for treating cancer, a composition and an application of the composition and particularly relates to a PI3 kinase regulator as well as a use method and application of the PI3 kinase regulator. The invention provides a compound as shown in the formula (I), a pharmaceutically accepted salt of the compound and a pharmaceutical preparation of the compound, wherein the compound is used for regulating the activity of protein kinase and intercellular or intracellular signal response. The invention also relates to a pharmaceutical composition containing the compound and a method for treating high-proliferative diseases of mammals and particularly human beings by using the pharmaceutical composition as shown in the formula (I).

Protozoan Parasite Growth Inhibitors Discovered by Cross-Screening Yield Potent Scaffolds for Lead Discovery

Tropical protozoal infections are a significant cause of morbidity and mortality worldwide; four in particular (human African trypanosomiasis (HAT), Chagas disease, cutaneous leishmaniasis, and malaria) have an estimated combined burden of over 87 million disability-adjusted life years. New drugs are needed for each of these diseases. Building on the previous identification of NEU-617 (1) as a potent and nontoxic inhibitor of proliferation for the HAT pathogen (Trypanosoma brucei), we have now tested this class of analogs against other protozoal species: T. cruzi (Chagas disease), Leishmania major (cutaneous leishmaniasis), and Plasmodium falciparum (malaria). Based on hits identified in this screening campaign, we describe the preparation of several replacements for the quinazoline scaffold and report these inhibitors' biological activities against these parasites. In doing this, we have identified several potent proliferation inhibitors for each pathogen, such as 4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-6-(4-((4-methyl-1,4-diazepan-1-yl)sulfonyl)phenyl)quinoline-3-carbonitrile (NEU-924, 83) for T. cruzi and N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-7-(4-((4-methyl-1,4-diazepan-1-yl)sulfonyl)phenyl)cinnolin-4-amine (NEU-1017, 68) for L. major and P. falciparum.