65473-14-5

Basic information

• Product Name: Naftifine hydrochloride
• Synonyms: N-TRANS-CINNAMYL-N-METHYL-(1-NAPHTHYLMETHYL)AMINE HYDROCHLORIDE;NAFTIFINE HCL;NAFTIFINE HYDROCHLORIDE;NAFTIFENE HYDROCHLORIDE;(e)-n-cinnamyl-n-methyl(1-naphthylmethyl)amine hydrochloride;Exoderil,Naftin(R),Suadian;Naftifine hyrdrochloride;Exoderil, Naftin, Suadian,
• CAS NO: 65473-14-5
• Molecular Formula: C21H22ClN
• Molecular Weight: 323.86
• EINECS: 1308068-626-2
• Product Categories: Miscellaneous Natural Products;API;Pharmaceuticals;Aromatics;Intermediates & Fine Chemicals;NAFTIN;antifungal
• Mol File: 65473-14-5.mol
• Article Data: 0

Chemical Properties

• Melting Point: 172-175°C
• Boiling Point: 440.1 °C at 760 mmHg
• Flash Point: 194.4 °C
• Appearance: /
• Storage Temp.: -20?C Freezer
• Solubility: ethanol: soluble50mg/mL
• Merck: 14,6355
• CAS DataBase Reference: Naftifine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Naftifine hydrochloride(65473-14-5)
• EPA Substance Registry System: Naftifine hydrochloride(65473-14-5)

Safety Data

• Safety Statements: 24/25
• WGK Germany: nwg
• RTECS: QJ8650000
• Hazardous Substances Data: 65473-14-5(Hazardous Substances Data)

Usage

Local antifungal agents

Naphthalene hydrochloride, also known as cinnamonyl methylamine, naphthalene, and naphthalene hydrochloride, is currently one of the commonly used drugs for fungal infection in Department of Dermatology, belonging to the local antifungal agents of acrylamines. It has bactericidal effect on the dermatophytes (Trichophyton, Microsporum and epidermis Trichophyton). It has bacteriostasis against Malassezia, Candida and other yeasts. It also has local bactericidal effect on Gram-positive and negative bacteria. The mechanism of its action is to inhibit the fungal squalene cyclooxygenase. It interferes with the biosynthesis of ergosterol in fungal cell wall. It affects the lipid metabolism of fungi and causes the damage or death of fungal cells to play a bactericidal and bacteriostasis effect. It is suitable for dermatophytosis caused by sensitive fungi, such as tinea corporis, tinea pedis, tinea capitis, onychomycosis, tinea versicolor, superficial candidiasis as well as erasing fungal disease in the skin folds. For the the external application of 1% Naftifine Hydrochloride Ointment on the skin by thehealthy people, about 3% to 6% of the doses can be absorbed.The concentration of naphthofinn on the surface of the skin at a single dose within 24 hours is sufficient to inhibit the growth of dermatitis. Naftifine can be converted to at least three metabolites through the oxidation of benzene ring and naphthalene and N- alkylation in the body. About 40% to 60% of the drugs in the body are excreted in the form of the original and metabolite form into the urine, and the rest is excreted into the feces by the bile. The half-life of the skin external use of naftifine is about 2~3 days. Usage and dosage: external use. For the skin infection, usually 1 times /d, and gently rub. The skin within 2.5cm centred on the infection should be coated with the drug. For erasing fungal disease, a ribbon gauze containing this product can be disposed at night in wrinkles. Duration of treatment: 2-4 weeks for dermatophyte infection and 8 weeks in severe cases; 4 weeks for superficial moniliasis;6 months for Onychomycosis ; 2 weeks for pityriasis versicolor. For the prevention of recurrence, the treatment continues for about 2 weeks after all the signs of infection have disappeared.

Uses

Different sources of media describe the Uses of 65473-14-5 differently. You can refer to the following data:
1. Used as antibiotic drugs, antifungal agents with broad spectrum and strong effect. The curative effect is good and fast with high the safety and survivability. It is for the treatment of dermatophyte infection, superficial moniliasis, Onychomycosis and skin and its accessories (hair finger, fingernail and toe) by achorion, microspore and epidermis Trichophyton. Indications include erasing mycosis of the lower breast as well as erasing mycosis between finger (toes), the buttocks, and the groin.This product has the characteristics of broad antifungal spectrum and low toxicity.
2. Antimycotic allylamine. An antifungal (topical) agent.
3. An antifungal agent

Description

Naftifine hydrochloride is a topical antifungal agent which acts via inhibiting squalene epoxidase. It demonstrates good activity against Trichophyton, Epidermophyton, Microsporum, Aspergillus, and species. It is the prototype of a significantly improved series of antifungal agents, exemplified by SF 86-327 in which the phenyl group of naftifine has been replaced by t-butylace tylene.

Chemical Properties

White Powder

Originator

Sandoz (Switzerland)

Brand name

Naftin (Merz);EXODERIL.

General Description

N-Methyl-N-(3-phenyl2-propenyl)-1-naphthalenemethanaminehydrochloride (Naftin) is a white crystallinepowder that is soluble in polar solvents such asethanol and methylene chloride. It is supplied in a 1% concentrationin a cream and in a gel for the topical treatmentof ringworm, athlete’s foot, and jock itch. Although unapprovedfor these uses, naftifine has shown efficacy fortreatment of ringworm of the beard, ringworm of the scalp,and tinea versicolor.

Clinical Use

Naftifine hydrochloride (Naftin) is available for topical use only in the treatment of cutaneous dermatophyte and Candida infections; it is as effective as topical azoles for these conditions.

InChI:InChI=1/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+;