656-60-0Relevant articles and documents
Metal-Free and User-Friendly Regioselective Hydroxyfluorination of Olefins
Sedgwick, Daniel M.,López, Inés,Román, Raquel,Kobayashi, Nanako,Okoromoba, Otome E.,Xu, Bo,Hammond, Gerald B.,Barrio, Pablo,Fustero, Santos
supporting information, p. 2338 - 2341 (2018/04/30)
A simple, user-friendly, metal-free protocol for the regioselective anti-Markovnikov hydrofluorination of olefins using readily available and inexpensive reagents has been developed. This new approach displays a broader scope than previously reported methodologies and has been applied to the late-stage fluorination of a complex molecule, giving rise to a fluorosteroid derivative. The stereochemistry of the process has also been studied in some detail.
Enzymatic preparation of (1S,2R)- and (1R,2S)-stereoisomers of 2-halocycloalkanols
Kolodiazhna, Olga O.,Kolodiazhna, Anastasy O.,Kolodiazhnyi, Oleg I.
, p. 37 - 42 (2013/02/25)
The stereoisomers of cis-2-halocycloalkanols were resolved by a kinetically controlled transesterification with vinyl acetate in the presence of lipases in organic media. High enantioselectivities (ee >98%) and good isolated yields were obtained for all substrates using the appropriate lipase. Burkholderia cepacia lipase was the most efficient enzyme for the resolution of these substrates. The enantiomeric purities of the compounds were defined by derivatization with Mosher's acid and the absolute configurations were determined by chemical correlation.
Fluorinated ε-caprolactone: Synthesis and ring-opening polymerization of new α-fluoro-ε-caprolactone monomer
Al-Azemi, Talal F.,Mohamod, Abdirahman A.
experimental part, p. 5431 - 5438 (2012/05/20)
Fluorinated polyester was synthesized from a novel α-fluoro-ε- caprolactone monomer (α-FCL). The monomer was synthesized from commercially available cyclohexene oxide in three steps. Baeyer-Villiger reaction using 3-chloroperoxybenzoic acid of the corresp
