65608-76-6

Basic information

• Product Name: Urea, N-[(4-chlorophenyl)methyl]-N'-ethyl-
• CAS NO: 65608-76-6
• Molecular Formula: C10H13ClN2O
• Molecular Weight: 212.679
• Mol File: 65608-76-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Urea, N-[(4-chlorophenyl)methyl]-N'-ethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Urea, N-[(4-chlorophenyl)methyl]-N'-ethyl-(65608-76-6)
• EPA Substance Registry System: Urea, N-[(4-chlorophenyl)methyl]-N'-ethyl-(65608-76-6)

Safety Data

• Hazardous Substances Data: 65608-76-6(Hazardous Substances Data)

Upstream product

• 14467-74-4 S-phenyl N-ethylthiocarbamate 
• 500582-62-7 ClC₆H₄CH₂N⁽²⁾H₂ 
• 104-86-9 4-chlorobenzylamine 

Relevant articles and documents

Kinetics and mechanism of the aminolysis of aryl N-ethyl thiocarbamates in acetonitrile

The aminolysis of aryl N-ethyl thiocarbamates (EtNHC(=O)SC 6H4Z) with benzylamines (XC6H 4-CN2NH2) in acetonitrile at 30.0 °C is investigated. The rates are faster than the corresponding values for aryl N-phenyl thiocarbamates (PhNHC(=O)SC6H4Z), reflecting a stronger push to expel the leaving group by EtNH than the PhNH nonleaving group in a concerted process. The negative ρXZ (-0.86) and failure of the reactivity-selectivity principle found are consistent with the concerted mechanism. The kinetic isotope effects involving deuterated nucleophiles (k H/kD = 1-5-1.7) and low ΔH? with large negative ΔS? values suggest a hydrogen bond cyclic transition state.