65610-14-2

Basic information

• Product Name: 4-FLUOROPHTHALONITRILE
• Synonyms: 1,2-DICYANO-4-FLUOROBENZENE;4-FLUOROBENZENE-1,2-DICARBONITRILE;4-FLUOROPHTHALONITRILE;4-fluoro-1,2-benzenedicarbonitrile;4-fluoro-2-benzenedicarbonitrile;1,2-Benzenedicarbonitrile,4-fluoro-(9CI);4-flurobenzene-1,2-dicaronitrile;4-Fluorophthalonitrle
• CAS NO: 65610-14-2
• Molecular Formula: C₈H₃FN₂
• Molecular Weight: 146.12
• EINECS: -0
• Product Categories: HALIDE;NITRILE;Aromatic Cinnamic Acids, Esters and Derivatives;Fluorine series
• Mol File: 65610-14-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 100-104 °C
• Boiling Point: 303.7 °C at 760 mmHg
• Flash Point: 137.5 °C
• Appearance: light yellow crystall powder
• Density: 1.27 g/cm³
• Vapor Pressure: 0.000917mmHg at 25°C
• Refractive Index: 1.538
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 2443236
• CAS DataBase Reference: 4-FLUOROPHTHALONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUOROPHTHALONITRILE(65610-14-2)
• EPA Substance Registry System: 4-FLUOROPHTHALONITRILE(65610-14-2)

Safety Data

• Hazard Codes: T+
• Statements: 28
• Safety Statements: 28-36/37-45
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• RTECS: CZ1942750
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 65610-14-2(Hazardous Substances Data)

Usage

Chemical Properties

white crystalline powder

Uses

4-Fluorophthalonitrile may be used in the synthesis of 2,29,20,2-tetrafluoropthalocyanito zinc(II).

General Description

4-Fluorophthalonitrile is an aryl fluorinated building block.

InChI:InChI=1/C8H3FN2/c9-8-2-1-6(4-10)7(3-8)5-11/h1-3H

Upstream product

• 56765-79-8 3,4-dicyanoaniline 
• 89-40-7 4-nitrophthalimide 
• 557-21-1 zinc(II) cyanide 
• 2369-37-1 1,2,-dibromo-4-fluorobenzene 
• 31643-49-9 4-Nitrophthalonitrile 

Downstream Products

• 507239-61-4 4-(2-methyl-4-pyrrolidin-1-yl-quinolin-7-ylmethoxy)-phthalonitrile 
• 507241-16-9 4-(4-chloro-2-methyl-quinolin-7-ylmethoxy)-phthalonitrile 
• 1262328-56-2 4-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-phthalonitrile 
• 893786-32-8 4-(4-formyl-2-methoxyphenoxy)phthalonitrile 
• 1242238-87-4 4-hydrazinylphthalonitrile 
• 1018700-03-2 N-(3,4-dicyanophenyl)-5-methoxytryptamine 
• 1018699-99-4 N-(3,4-dicyanophenyl)tryptamine 
• 401565-01-3 3-[(2S,4S)-1-tert-butoxycarbonyl-4-(3,4-dicyanophenyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine 

Relevant articles and documents

Palladium(II) phthalocyanines efficiently promote phosphine-free Sonogashira cross-coupling reaction at room temperature

Herein we report that exceptionally simple and inexpensive Pd(II) complexes of phthalocyanines efficiently catalyze direct formation of diphenylacetylenes at ambient conditions with low loading of catalyst (0.5 mol%). Results of this study demonstrate that terminal alkynes reacted mildly with p-substituted aryl bromides at room temperature under Pd and Cu-cocatalysis to give the corresponding phenylacetylenes in yields up to 98%. Also we have examined this catalyst in Sonogashira cross-coupling with aryl chlorides and it was very effective and this reaction at room temperature that there is no examples in recent articles. This protocol represents the first use of palladium phthalocyanine as homogeneous catalyst in the Pd/Cu-promoted Sonogashira reaction. The palladium(II) phthalocyanine complex is significantly more active in Sonogashira cross-coupling between aryl halides and terminal alkynes as compared with traditional catalysts because of absence of palladium black formation through agglomeration of metal particles and deactivation of catalyst.

Versatile application of trifluoromethyl triflate

Hydrolytically stable and easy to handle trifluoromethyl triflate was found to be a liquid reservoir of 'masked' difluorophosgene. Anhydrous F- sources cleave the S-O bond in trifluoromethyl triflate yielding quantitatively the trifluoromethanolate salts, being useful trifluoromethoxy group carriers. Reaction of trifluoromethanolates with in situ generated from o-trimethylsilylphenyl triflate benzyne leads to (trifluoromethoxy)benzene and fluorobenzene (ratio 85:15). Whereas an addition of trifluoromethanethiolate anion across a triple bond of benzyne leads to [(trifluoromethyl)sulfanyl]benzene solely.