65693-79-0

Basic information

• Product Name: Acetamide, N-1-propenyl-
• CAS NO: 65693-79-0
• Molecular Formula: C5H9NO
• Molecular Weight: 99.1326
• Mol File: 65693-79-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetamide, N-1-propenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-1-propenyl-(65693-79-0)
• EPA Substance Registry System: Acetamide, N-1-propenyl-(65693-79-0)

Safety Data

• Hazardous Substances Data: 65693-79-0(Hazardous Substances Data)

Upstream product

• 60-35-5 acetamide 
• 201230-82-2 carbon monoxide 
• 123-38-6 propionaldehyde 

Relevant articles and documents

Synthesis of N-Acetyl-α-aminobutyric Acid via Amidocarbonylation: A Case Study

The synthesis of N-acetyl-α-aminobutyric acid by amidocarbonylation of propionaldehyde with acetamide in the presence of palladium catalysts is studied in detail. The influence of various reaction conditions and compositions (e.g., the co-catalysts acid and bromide) on the yield of N-acetyl-α-aminobutyric acid is shown. For the first time it is demonstrated that the palladium-catalyzed amidocarbonylations of aldehydes can be run with significantly lower halide concentrations (a major yield decrease. While phosphine-free catalyst systems give best yields at low CO pressure, phosphine-ligated palladium catalysts lead to better yields at higher CO pressure. At low palladium loadings (0.1 mol %), unwanted condensation reactions of propionaldehyde become increasingly competitive.