657393-34-5

Basic information

• Product Name: (E)-3-{3-methoxy-4-[(1S)-methyl-2-oxo-2-(3,4,5-trimethoxy-phenyl)-ethoxy]-phenyl}-acrylic acid ethyl ester
• CAS NO: 657393-34-5
• Molecular Weight: 444.482
• Mol File: 657393-34-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-3-{3-methoxy-4-[(1S)-methyl-2-oxo-2-(3,4,5-trimethoxy-phenyl)-ethoxy]-phenyl}-acrylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-{3-methoxy-4-[(1S)-methyl-2-oxo-2-(3,4,5-trimethoxy-phenyl)-ethoxy]-phenyl}-acrylic acid ethyl ester(657393-34-5)
• EPA Substance Registry System: (E)-3-{3-methoxy-4-[(1S)-methyl-2-oxo-2-(3,4,5-trimethoxy-phenyl)-ethoxy]-phenyl}-acrylic acid ethyl ester(657393-34-5)

Safety Data

• Hazardous Substances Data: 657393-34-5(Hazardous Substances Data)

Upstream product

• 4046-02-0 ethyl 4-hydroxy-3-methoxycinnamate 
• 657393-28-7 toluene-4-sulfonic acid (1R)-methyl-2-oxo-2-(3,4,5-trimethoxy-phenyl)-ethyl ester 
• 443684-50-2 (2R)-hydroxy-1-(3,4,5-trimethoxy-phenyl)-propan-1-one 
• 20675-95-0 (E)-2,6,-dimethoxy-4-(prop-1-en-1-yl)phenol 
• 487-12-7 isoelemicin 
• 6627-88-9 4-allyl-2,6-dimethoxyphenol 
• 657393-24-3 (1R,2R)-1-(3,4,5-trimethoxyphenyl)propane-1,2-diol 

Relevant articles and documents

The synthesis of the anti-malarial natural product polysphorin and analogues using polymer-supported reagents and scavengers.

A general asymmetric route to both enantiomers of polysphorin has been developed. The route utilizes polymer-supported reagents, catalysts and scavengers to minimise the need for aqueous work-up and chromatography. This includes application of a method to scavenge 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and a "catch-and-release" procedure to extract the resultant diol following Sharpless asymmetric dihydroxylation. A novel enzymatic selective protection and investigations of a new asymmetric dihydroxylation using microencapsulated osmium tetroxide were also investigated during the course of this study.