65872-41-5

Basic information

• Product Name: 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid
• Synonyms: 2-Amino-α-(methoxyimino)-4-thiazoleacetic acid;(Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetic Acid;2-aminothiazole-methoxyiminoaceticacid;2-Methoxylimino-2-(2-aminothiozol)-4-aceticacid;Aminothiaoximinoacid;Aminothiaoximoacid;2-(2-AMINOTHIAZOLE-4-YL)-2-METHOXYIMINOACETIC ACID;4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-(METHOXYIMINO)-
• CAS NO: 65872-41-5
• Molecular Formula: C₆H₇N₃O₃S
• Molecular Weight: 201.2
• EINECS: 265-957-0
• Product Categories: Organic acids;Cephalosporins;Building Blocks;Heterocyclic Building Blocks;Thiazoles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Building Blocks;C3 to C7;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 65872-41-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 192 °C (dec.)(lit.)
• Boiling Point: 425.1 °C at 760 mmHg
• Flash Point: 210.9 °C
• Appearance: /solid
• Density: 1.463 (estimate)
• Vapor Pressure: 5.53E-08mmHg at 25°C
• Refractive Index: 1.6630 (estimate)
• Storage Temp.: -20?C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• PKA: 2.97±0.10(Predicted)
• Water Solubility: 0.6 g/100 mL (20 ºC)
• CAS DataBase Reference: 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid(65872-41-5)
• EPA Substance Registry System: 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid(65872-41-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-24/25
• WGK Germany: 3
• Hazardous Substances Data: 65872-41-5(Hazardous Substances Data)

Usage

Chemical Properties

OFF-WHITE TO BEIGE POWDER

InChI:InChI=1/C6H7N3O3S/c1-12-9-4(5(10)11)3-2-13-6(7)8-3/h2H,1H3,(H2,7,8)(H,10,11)/p-1/b9-4-

Upstream product

• 80756-85-0 (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate 
• 64486-18-6 2-(2-chloroacetylaminothiazole-4-yl)-2-(Z)-methoxyiminoacetic acid 
• 137-42-8 sodium N-methyldithiocarbamate 
• 65243-09-6 2-(2-aminothiazol-4-yl)-2-syn-methoxyiminoacetic acid methyl ester 
• 64485-88-7 ethyl 2-(2-aminothiazol-4-yl)-2-(anti)-methoxyiminoacetate 
• 80756-29-2 2-methoxyimino-3-oxo-4,4-dibromobutyric acid 

Downstream Products

• 141061-25-8 4-Methoxybenzyl (6R,7R)-7-[2-(2-aminothiazol-4-yl)-2-(Z)-methoxyiminoacetamido]-3-[(R)-tetrahydrofuran-2-yl]-ceph-3-em-4-carboxylate 
• 141194-73-2 4-Methoxybenzyl (6R,7R)-7-[2-(2-aminothiazol-4-yl)-2-(Z)-methoxyiminoacetamido]-3-[(5R,2R)-5-methyltetrahydro-furan-2-yl]ceph-3-em-4-carboxylate 
• 141072-80-2 4-Methoxybenzyl (6R,7R)-7-[2-(2-aminothiazol-4-yl)-2-(Z)-methoxyiminoacetamido]-3-[(S)-5,5-dimethyltetrahydrofuran-2-yl]ceph-3-em-4-carboxylate 
• 64486-18-6 2-(2-chloroacetylaminothiazole-4-yl)-2-(Z)-methoxyiminoacetic acid 

Relevant articles and documents

Antibiotic-improved cefmenoxime hydrochloride synthesis process

The invention discloses an antibiotic-improved cefmenoxime hydrochloride synthesis process, which comprises the following steps: step 1, preparation of 1-methyl-5-sulfydryl-1H-tetrazole, step 2, preparation of 2-(2-amino-4-azolyl)-2(Z)-methoxyimino ethyl acetate; step 3, preparation of 2-(2-amino-4-thiazolyl)-2-(Z)-methoxyimino acetic acid; step 4, preparation of 2-(2-amino-4-thiazolyl)-2-(Z)-methoxyimino acetic acid-2-benzothiazole thioester; step 5, preparation of 7-amino-3-(1-methyl-1H-tetrazole-5-thiomethyl)cephalosporanic acid hydrochloride (7-ACA-MMT. HC1); and step 6, preparation of cefmenoxime hydrochloride; domestic raw materials are adopted, the raw materials are cheap and easy to obtain in the synthesis route, the synthesis cost is reduced, and synthesis is improved; the improved process has the advantages of low raw material cost, simplicity in operation and suitability for industrial production.

Process for producing chloroacetylaminothiazoleacetic acid derivatives

The present invention relates to a simple process for producing 2-aminothiazoleacetic acid derivatives useful as intermediates for producing cephalosporin-type antibiotics. The process for producing chloroacetylaminothiazoleacetic acid derivatives represented by the following formula (II) ???wherein R1 is a protection group for the hydroxyl group,comprises reacting aminothiazoleacetic acid derivatives represented by the following formula (I) ???wherein R1 is a protection group for the hydroxyl group,with a chloroacetylating agent.

Triazolo-pyrimidine intermediates

There are disclosed a β-lactam compound represented by the formula (I): STR1 wherein R1 represents an acyl group; M represents a hydrogen atom, a protective group of an eliminatable group which is easily hydrolyzable in a human body; B represents a group represented by the formula (b): STR2 where at least one of R2, R3 and R9 represent a group represented by the formula: -A-OR4 where R4 represents a hydrogen or a lower alkyl group; and A represents a straight or branched alkylene group having 1 to 6 carbon atoms; and a remaining group or groups are each independently a hydrogen atom; a cyano group; a lower alkyl group which may be substituted by a halogen atom; a carbamoyl group which may be substituted by a lower alkyl group; a cycloalkyl group; or a carboxyl group which may be substituted by a protective group of an eliminatable group which is easily hydrolyzable in a human body, and also when R9 is -A-OR4, R2 and R3 may be combined with each other to form an alkylene group having 3 to 4 carbon atoms; and Z represents a nitrogen atom or a group represented by the formula: C-R10 where R10 represents a hydrogen atom, a carboxyl group or a lower alkyl group which may be substituted by a hydroxy group or a lower alkoxy group, or its pharmaceutically acceptable salt, and a process for preparing the same, an intermediate for synthesis of the same and a medicinal composition for bacterially infectious disease therapy containing the same.