659-28-9

Basic information

• Product Name: 4-(Trifluoromethoxy)benzaldehyde
• Synonyms: α,α,α-trifluoroanisaldehyde;4-(Trifluoromethoxy)benzaldehyde 98%;4-(Trifluoromethoxy)benzaldehyde98%;Benzaldehyde, 4-(trifluoromethoxy)-;4-(Trifluoromethoxy)benzaldehyde,99%;On trifluoroMethoxy benzaldehyde;4-(TRIFLUOROMETHOXY)BENZALDEHYDE FOR SYN;For trifluoromethoxy benzaldehyde
• CAS NO: 659-28-9
• Molecular Formula: C₈H₅F₃O₂
• Molecular Weight: 190.12
• EINECS: 211-531-4
• Product Categories: Trifluoroanisole series;Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;Benzaldehyde series;Pyridines
• Mol File: 659-28-9.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 93 °C27 mm Hg(lit.)
• Flash Point: 159 °F
• Appearance: Clear colorless to pale yellow-green/Liquid
• Density: 1.331 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.438mmHg at 25°C
• Refractive Index: n20/D 1.458(lit.)
• Storage Temp.: Store below +30°C.
• Sensitive: Air Sensitive
• BRN: 1949135
• CAS DataBase Reference: 4-(Trifluoromethoxy)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Trifluoromethoxy)benzaldehyde(659-28-9)
• EPA Substance Registry System: 4-(Trifluoromethoxy)benzaldehyde(659-28-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36/38-22
• Safety Statements: 26-36/37/39-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 659-28-9(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless to pale yellow-green liquid

Uses

4-(Trifluoromethoxy)benzaldehyde is suitable for use in the synthesis of (E)-4-(trifluoromethoxy)benzaldehyde thiosemicarbazone. It may be used in the synthesis of:new azo dyes containing of 5(4H)-oxazolone ring2-[4-(trifluoromethoxy)phenyl]-1H-benzimidazole(E)-2-[4-(trifluoromethoxy)benzylidene]indan-1-one.

General Description

4-(Trifluoromethoxy)benzaldehyde (p-(trifluoromethoxy)benzaldehyde) is an aromatic aldehyde. It participates in the synthesis of 4,5-dihydro-4-(4-trifluoromethoxyphenyl)pyrrolo[1,2-a]quinoxaline.

InChI:InChI=1/C8H5F3O2/c9-8(10,11)13-7-3-1-6(5-12)2-4-7/h1-5H

Upstream product

• 201230-82-2 carbon monoxide 
• 456-55-3 1-trifluoromethoxybenzene 
• 407-14-7 1-bromo-4-(trifluoromethoxy)benzene 
• 68-12-2 N,N-dimethyl-formamide 
• 100-97-0 hexamethylenetetramine 
• 100-52-7 benzaldehyde 
• 927-84-4 bis(trifluoromethyl)peroxide 
• 4394-85-8 4-morpholinecarboxaldehyde 
• 330-12-1 4-trifluoromethoxybenzoic acid 
• 1736-74-9 4-trifluoromethoxybenzyl alcohol 
• 332-25-2 4-(trifluoromethoxy)benzonitrile 

Downstream Products

• 181260-41-3 N-4-trifluoromethoxybenzylidene-1,1-diphenylmethylamine 
• 866207-69-4 (E)-ethyl 3-(4-(trifluoromethoxy)phenyl)acrylate 
• 186184-48-5 (2E,4E)-5-(4-Trifluoromethoxy-phenyl)-penta-2,4-dienoic acid ethyl ester 
• 500163-45-1 (+/-)-methyl 2-{hydroxy[4-(trifluoromethoxy)phenyl]methyl}acrylate 
• 1736-74-9 4-trifluoromethoxybenzyl alcohol 
• 150162-39-3 N-hydroxy-1-[4-(trifluoromethoxy)phenyl]methaneimine 
• 951231-98-4 (E)-4-(4-(trifluoromethoxy)-phenyl)-but-3-en-2-one 
• 783-13-1 4-trifluoromethoxycinnamic acid 
• 690273-26-8 N-[4-(4-Methylthiazol-2-yl)-1-[4-(trifluoromethoxy)benzyl]-4-piperidinyl]-N-phenylacetamide 

Relevant articles and documents

Mild oxidation of benzyl alcohols to benzyl aldehydes or ketones catalyzed by visible light

Induced by visible light, mild oxidation condition to prepare benzyl aldehydes or ketones have been developed by using bromotrichloromethane as photochemical oxidant. This method avoids high temperature, pressure and peroxidation with only visible light as the green driving force.

Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow

The first example of photocatalytic trifluoromethoxylation of arenes and heteroarenes under continuous-flow conditions is described. Application of continuous-flow microreactor technology allowed to reduce the residence time up to 16 times in comparison t

TEMPO-mediated oxidation of primary alcohols to aldehydes under visible light and air

A homogeneous visible light photoredox TEMPO-mediated selective oxidation of primary alcohols to the corresponding carbonyl compounds was developed using molecular oxygen from air as the terminal oxidant. Ru(bpy)3(PF 6)2 (bpy: bipyridyl) and Ir(dtb-bpy)(ppy) 2(PF6) (dtb-bpy: 4,4′-di-tert-butyl-2,2′- bipyridyl; ppy: 2-phenylpyridine) were used as the sensitizers. A homogeneous visible light photoredox TEMPO-mediated selective oxidation of primary alcohols to the corresponding carbonyl compounds was developed. Molecular oxygen from air was the terminal oxidant. Copyright