659-41-6

Basic information

• Product Name: 4-FLUORO BENZYLAMINE HYDROCHLORIDE
• Synonyms: 4-FLUORO BENZYLAMINE HYDROCHLORIDE;4-Fluoro Benzylamine HCl;p-fluorobenzylamine hydrochloride;(4-Fluorophenyl)methanamine hydrochloride
• CAS NO: 659-41-6
• Molecular Formula: C₇H₈FN*ClH
• Molecular Weight: 161.6
• EINECS: 211-534-0
• Product Categories: Anilines, Amides & Amines;Fluorine Compounds
• Mol File: 659-41-6.mol
• Article Data: 38

Chemical Properties

• Melting Point: 265-268 °C(Solv: ethanol (64-17-5))
• Boiling Point: 184.3 °C at 760 mmHg
• Flash Point: 73.3 °C
• Appearance: /
• Vapor Pressure: 0.738mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: Soluble in water
• CAS DataBase Reference: 4-FLUORO BENZYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO BENZYLAMINE HYDROCHLORIDE(659-41-6)
• EPA Substance Registry System: 4-FLUORO BENZYLAMINE HYDROCHLORIDE(659-41-6)

Safety Data

• Hazardous Substances Data: 659-41-6(Hazardous Substances Data)

Usage

General Description

4-Fluoro Benzylamine Hydrochloride is a chemical compound that consists of a benzene ring with a fluorine atom and an amine group attached. It is commonly used in the synthesis of various pharmaceuticals and agrochemicals. 4-FLUORO BENZYLAMINE HYDROCHLORIDE is also used as a reagent in organic chemistry reactions, particularly in the formation of carbon-carbon and carbon-nitrogen bonds. It is a white crystalline solid that is soluble in water and organic solvents. 4-Fluoro Benzylamine Hydrochloride is an important intermediate in the production of various chemicals and is widely utilized in the pharmaceutical industry.

InChI:InChI=1/C7H8FN.ClH/c8-7-3-1-6(5-9)2-4-7;/h1-4H,5,9H2;1H

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 403-43-0 4-fluorobenzoyl chloride 
• 1849-02-1 2-chloro-1-methyl-benzimidazole 
• 140-75-0 para-fluorobenzylamine 
• 1535-41-7 1-fluoro-4-(nitromethyl)benzene 
• 824-75-9 p-fluorobenzamide 
• 1402844-52-3 1-(4-fluorobenzyl)-3,4-diphenyl-1H-pyrrole-2,5-dione 
• 1194-02-1 4-fluorobenzonitrile 
• 159979-96-1 4-fluorobenzyl azide 
• 352-11-4 1-chloromethyl-4-fluorobenzene 

Downstream Products

• 780-22-3 (4-fluoro-benzyl)-carbamic acid-(2-fluoro-ethyl ester) 
• 76523-24-5 1-(4-fluorophenyl)methylurea 
• 144054-88-6 3,7-dimethyl-9-p-fluorobenzylamino-3,7-diazabicyclo<3.3.1>nonane-9-carbonitrile 
• 105686-00-8 1-(4-fluorobenzyl)imidazolidinetrione 
• 128043-70-9 ethyl 1-(4-fluorobenzyl)-2,4,5-trioxoimidazolidine-3-acetate 
• 144054-84-2 3,7-dimethyl-9-p-fluorobenzylamino-3,7-diazabicyclo<3.3.1>nonane-9-carboxamide dihydrochloride 
• 458-72-0 N-[(4-fluorophenyl)methyl]thiazole 2-amine 
• 3830-97-5 N-(4-fluoro-benzyl)-N',N'-dimethyl-N-thiazol-2-yl-ethylenediamine 
• 73733-74-1 N-<(4-fluorophenyl)methyl>-3-nitro-2-pyridinamine 
• 187818-85-5 Pd(OOCCH₃)2(H₂NCH₂C₆H₄F)2 
• 652147-99-4 8-(4-fluoro-benzyl)-8-aza-bicyclo[3.2.1]octan-3-one 
• 1163740-02-0 carboxyeremomycin AA₃,AA₇-bis[N-(p-fluorobenzyl)amide] 
• 1163739-89-6 eremomycin AA₇-N-(p-fluorobenzyl)amide 
• 1333500-45-0 C₁₅H₂₀FN₅*ClH 

Relevant articles and documents

Cyclic (Alkyl)(amino)carbene Ligand-Promoted Nitro Deoxygenative Hydroboration with Chromium Catalysis: Scope, Mechanism, and Applications

Transition metal catalysis that utilizes N-heterocyclic carbenes as noninnocent ligands in promoting transformations has not been well studied. We report here a cyclic (alkyl)(amino)carbene (CAAC) ligand-promoted nitro deoxygenative hydroboration with cost-effective chromium catalysis. Using 1 mol % of CAAC-Cr precatalyst, the addition of HBpin to nitro scaffolds leads to deoxygenation, allowing for the retention of various reducible functionalities and the compatibility of sensitive groups toward hydroboration, thereby providing a mild, chemoselective, and facile strategy to form anilines, as well as heteroaryl and aliphatic amine derivatives, with broad scope and particularly high turnover numbers (up to 1.8 × 106). Mechanistic studies, based on theoretical calculations, indicate that the CAAC ligand plays an important role in promoting polarity reversal of hydride of HBpin; it serves as an H-shuttle to facilitate deoxygenative hydroboration. The preparation of several commercially available pharmaceuticals by means of this strategy highlights its potential application in medicinal chemistry.

Deoxygenation of primary amides to amines with pinacolborane catalyzed by Ca[N(SiMe3)2]2(THF)2

Deoxygenative reduction of amides is a challenging but favorable synthetic method of accessing amines. In the presence of a catalytic amount of Ca[N(SiMe3)2]2(THF)2, pinacolborane (HBpin) could efficiently reduce a broad scope of amides, primary amides in particular, into corresponding amines. Functional groups and heteroatoms showed good tolerance in this process of transformation, and a plausible reaction mechanism was proposed.

Deoxygenative hydroboration of primary, secondary, and tertiary amides: Catalyst-free synthesis of various substituted amines

Transformation of relatively less reactive functional groups under catalyst-free conditions is an interesting aspect and requires a typical protocol. Herein, we report the synthesis of various primary, secondary, and tertiary amines through hydroboration of amides using pinacolborane under catalyst-free and solvent-free conditions. The deoxygenative hydroboration of primary and secondary amides proceeded with excellent conversions. The comparatively less reactive tertiary amides were also converted to the corresponding N,N-diamines in moderate yields under catalyst-free conditions, although alcohols were obtained as a minor product.