65950-13-2

Basic information

• Product Name: 2-Pyrrolidinemethanol, 1-benzoyl-, (2S)-
• CAS NO: 65950-13-2
• Molecular Formula: C12H15NO2
• Molecular Weight: 205.257
• Mol File: 65950-13-2.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2-Pyrrolidinemethanol, 1-benzoyl-, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrrolidinemethanol, 1-benzoyl-, (2S)-(65950-13-2)
• EPA Substance Registry System: 2-Pyrrolidinemethanol, 1-benzoyl-, (2S)-(65950-13-2)

Safety Data

• Hazardous Substances Data: 65950-13-2(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 55-21-0 benzamide 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 56439-58-8 N,O-Dibenzoyl-L-prolinol 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 147-85-3 L-proline 
• 5493-38-9 N-benzoyl-L-proline methyl ester 
• 72351-42-9 [2-(hydroxymethyl)-1-pyrrolidinyl](phenyl)methanone 

Downstream Products

• 2315-68-6 propyl benzoate 
• 136-60-7 benzoic acid, butyl ester 
• 478385-97-6 (2S)-1-benzoyl-2-fluoromethylpyrrolidine 
• 106865-54-7 N-benzoyl-L-2<(methylthio)methyl>pyrrolidine 
• 65950-14-3 (2S)-1-benzoylpyrrolidin-2-al 
• 106865-53-6 N-benzoyl-L-(+)-2-<(phenylthio)methyl>pyrrolidine 

Relevant articles and documents

Chemoselective Intramolecular Formal Insertion Reaction of Rh–Nitrenes into an Amide Bond Over C?H Insertion

The past few decades have witnessed extensive efforts to disclose the unique reactivity of metal–nitrenes, because they could be a powerful synthetic tool for introducing the amine functionality into unactivated chemical bonds. The reactivity of metal–nitrenes, however, is currently mainly confined to aziridination (an insertion into a C=C bond) and C?H amination (an insertion into a C?H bond). Nitrene insertion into an amide C?N bond, however, has not been reported so far. In this work we have developed a rhodium-catalyzed one-nitrogen insertion into amide C?N and sulfonamide S?N bonds. Experimental and theoretical analyses based on density functional theory indicate that the formal amide insertion proceeds via a rhodium-coordinated ammonium ylide formed between the nitrene and the amide nitrogen, followed by acyl group transfer concomitant with C?N bond cleavage. Mechanistic studies have allowed rationalization of the origin of the chemoselectivity observed between the C?H and amide insertion reactions. The methodology presented herein is the first example of an insertion of nitrene into amide bonds and provides facile access to unique diazacyclic systems with an N?N bond linkage.

Simple methodology for the preparation of amino alcohols from amino acid esters using nabh4-methanol in THF

Amino alcohols constitute a very useful and versatile class of organic compounds, with important applications in synthetic and medicinal chemistry. However, in most of the procedures described in the literature for the obtainment of these compounds, considerable limitations can be found, such as drastic conditions, long time reactions, poor yields, and purification problems. The present article describes a methodology that gives amino alcohols and N-protected amino alcohols based on the reduction of amino acid esters under mild conditions, employing NaBH4 in the presence of methanol. The reactions occurred in a short time (15-20min) and provide yields of 50-95%.

1,5-DIHETEROCYCLE-1H-TRIAZOLE DERIVATIVE

The present invention relates to a compound represented by Formula (I): wherein Ar1, Ar2, R1 and R2 each represent a substituent, a salt thereof, or a solvate of the compound or the salt, and to a medicine containing the same. According to the present invention, a potent platelet aggregation suppressant which does not inhibit COX-1 and COX-2 is provided.