6597-25-7

Basic information

• Product Name: 2-(4-nitrophenyl)-3H-indol-3-one N-oxide
• Synonyms: 2-(4-nitrophenyl)-3H-indol-3-one N-oxide
• CAS NO: 6597-25-7
• Molecular Weight: 268.229
• Mol File: 6597-25-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(4-nitrophenyl)-3H-indol-3-one N-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-nitrophenyl)-3H-indol-3-one N-oxide(6597-25-7)
• EPA Substance Registry System: 2-(4-nitrophenyl)-3H-indol-3-one N-oxide(6597-25-7)

Safety Data

• Hazardous Substances Data: 6597-25-7(Hazardous Substances Data)

Upstream product

• 937-31-5 (4-Nitrophenyl)acetylene 
• 609-73-4 o-nitroiodobenzene 
• 552-89-6 2-nitro-benzaldehyde 
• 4329-73-1 N-(4-nitrobenzyl)pyridinium bromide 
• 14344-93-5 1-(4,2'-dinitro-stilben-α-yl)-pyridinium; bromide 
• 107127-62-8 (E)-3-Morpholin-4-yl-2-(4-nitro-phenyl)-1-(2-nitro-phenyl)-propenone 
• 81884-18-6 2-(4-Nitro-phenyl)-1-(2-nitro-phenyl)-ethanone 
• 408321-17-5 2-((4-nitrophenyl)ethynyl)nitrobenzene 

Downstream Products

• 13054-57-4 2-amino-3a-(4-nitro-phenyl)-4-oxo-3a,4-dihydro-isoxazolo[2,3-a]indole-4-carboxylic acid ethyl ester 
• 58497-48-6 benzo[c]isoxazol-3-yl(4-nitrophenyl)methanone 
• 855612-51-0 2-(4-nitro-phenyl)-indol-3-ol 

Relevant articles and documents

Synthesis and antiplasmodial activity of new indolone N-Oxide derivatives

A series of 66 new indolone-N-oxide derivatives was synthesized with three different methods. Compounds were evaluated for in vitro activity against CQ-sensitive (3D7), CQ-resistant (FcB1), and CQ and pyrimethamine cross-resistant (K1) strains of Plasmodium falciparum (P.f.), aswell as for cytotoxic concentration (CC50) on MCF7 and KB human tumor cell lines. Compound 26 (5-methoxy-indolone-N-oxide analogue) had the most potent antiplasmodial activity in vitro (50 MCF7/IC50 FcB1: 14623; CC50 KB/IC50 3D7: 198823). In in vivo experiments, compound 1 (dioxymethylene derivatives of the indolone-N-oxide) showed the best antiplasmodial activity against Plasmodium berghei, 62% inhibition of the parasitaemia at 30 mg/kg/day. 2009 American Chemical Society.

Enamines: Part III - A New Synthesis of Substituted 2-Arylisatogens and o-Nitrophenyl Benzyl Ketones

Condensation of substituted o-nitrobenzoyl chloride with o/p-nitro substituted β-morpholinostyrenes gives α-acyl-β-morpholinostyrenes which are converted into the title compounds.