66051-40-9

Basic information

• Product Name: 2-Propenoic acid, 2-chloro-3-(4-methoxyphenyl)-, ethyl ester, (2Z)-
• CAS NO: 66051-40-9
• Molecular Formula: C12H13ClO3
• Molecular Weight: 240.686
• Mol File: 66051-40-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 2-chloro-3-(4-methoxyphenyl)-, ethyl ester, (2Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 2-chloro-3-(4-methoxyphenyl)-, ethyl ester, (2Z)-(66051-40-9)
• EPA Substance Registry System: 2-Propenoic acid, 2-chloro-3-(4-methoxyphenyl)-, ethyl ester, (2Z)-(66051-40-9)

Safety Data

• Hazardous Substances Data: 66051-40-9(Hazardous Substances Data)

Upstream product

• 7071-12-7 triethyl 2-chloro-2-phosphonoacetate 
• 5823-12-1 ethyl 2,2-dichloro-2-diethoxyphosphorylacetate 
• 123-11-5 4-methoxy-benzaldehyde 
• 791131-05-0 ethyl chloro(diphenylphosphono)acetate 
• 515-84-4 Ethyl trichloroacetate 
• 64-17-5 ethanol 
• 41448-64-0 1-(2,2-dichlorovinyl)-4-methoxybenzene 
• 201230-82-2 carbon monoxide 

Downstream Products

• 1619970-78-3 (E)-ethyl 2-(4-methoxybenzylidene)-4-oxo-4-phenylbutanoate 

Relevant articles and documents

Pd0-Catalyzed carbonylation of 1,1-dichloro-1-alkenes, a new selective access to Z-α-chloroacrylates

A novel and fully chemo- and stereoselective three component strategy leading to Z-α-chloroacrylates by a Pd0-catalyzed reaction of CO (1 atm) with 1,1-dichloro-1-alkenes and various alcohols is disclosed. This catalytic approach compares favourably with the Wittig type strategies as α-chloroacrylates of pure Z configuration are obtained in high yield. The Royal Society of Chemistry.

One-pot process in phosphonium-iodonium ylides: Nucleophilic substitution and the Wittig reaction

The nucleophilic substitution in mixed phosphonium-iodonium ylides was investigated. The iodonium group is replaced by such S-containing nucleophiles as the thiocyanate anion or thiourea, as well as by halide ions. The structure of the reaction product with the thiocyanate ion was established by X-ray diffraction. A one-pot process involving the nucleophilic substitution and the Wittig reaction was developed.

Stereoselective preparation of (E)-α-bromoacrylates from mixtures of brominated ando phosphonates

We prepared 69:31-11:89 mixtures of phosphonates 6b and 7b containing two phenoxy substituents, a CO2Et group, and 1 or 2 bromine atoms, respectively, at the interspersed methylene group. Deprotonating 64:36 mixtures of these reagents with NaH