66104-23-2 Usage
Description
Different sources of media describe the Description of 66104-23-2 differently. You can refer to the following data:
1. Pergolide mesylate is a potent, long-acting dopamine agonist useful in the treatment of
Parkinson’s disease and hyperprolactinemia, Compared with lergotrile, pergolide mesylate
has shown less toxicity and lower propensity for inducing psychosis.
2. Pergolide is a potent dopamine D1 and D2 receptor agonist (Kis = 111 and 0.495 nM, respectively, for rat striatal receptors). It depresses dopaminergic firing in paralyzed rats (ED50 = <20 μg/kg), an effect that can be reversed by the dopamine D2-selective antagonist spiperone or the dopamine D1-selective antagonist SCH 23390 . Pergolide (0.025 and 0.05 mg/kg) increases the volume threshold for inducing bladder contraction in a cynomolgus monkey model of Parkinson''s disease induced by MPTP. It also reduces carrageenan-induced paw edema in adrenalectomized rats (ED50 = 0.4 mg/kg).
Chemical Properties
White to Off-White Solid
Uses
A dopaminergic agonist that also decrease plasma prolactin concentrations. An antiparkinsonian agent
Definition
ChEBI: A methanesulfonate salt obtained from pergolide by mixing eqimolar amount of pergolide and methanesulfonic acid. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it i
used in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction.
Biochem/physiol Actions
Dopaminergic agonist; suppresses pituitary secretion of prolactin; anti-Parkinsonian agent.
Check Digit Verification of cas no
The CAS Registry Mumber 66104-23-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,1,0 and 4 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 66104-23:
(7*6)+(6*6)+(5*1)+(4*0)+(3*4)+(2*2)+(1*3)=102
102 % 10 = 2
So 66104-23-2 is a valid CAS Registry Number.
InChI:InChI=1/C19H26N2S.CH4O3S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21;1-5(2,3)4/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3;1H3,(H,2,3,4)/t13-,16-,18-;/m1./s1
66104-23-2Relevant articles and documents
Development of a practical high-yield industrial synthesis of pergolide mesylate
Cabri, Walter,Roletto, Jacopo,Olmo, Sara,Fonte, Piera,Ghetti, Paolo,Songia, Simonetta,Mapelli, Elio,Alpegiani, Marco,Paissoni, Paolo
, p. 198 - 202 (2012/12/22)
The development of a high-yield and low environmental impact synthesis able to deliver highly pure pergolide mesylate 1 is described. The process [seven chemical steps (four telescoped), three steps of isolation of intermediate, and only one drying] affords pergolide mesylate 1 in 75-81% overall yield from dihydrolysergic acid 4 with >99.8% purity.
6-N-Propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
-
, (2008/06/13)
6-n-Propyl (ethyl or allyl)-8β-methoxy-(methylsulfinyl, methylsulfonyl, or methylmercapto) methylergolines, 8-ergolenes or 9-ergolenes, useful as prolactin inhibitors and in the treatment of Parkinsonism.
