66134-67-6

Basic information

• Product Name: Succinimido p-fluorobenzoate
• Synonyms: 2,5-Pyrrolidinedione, 1-[(4-fluorobenzoyl)oxy]-;Succinimido p-fluorobenzoate;2,5-Dioxopyrrolidin-1-yl 4-fluorobenzoate
• CAS NO: 66134-67-6
• Molecular Formula: C₁₁H₈FNO₄
• Molecular Weight: 237.18
• Mol File: 66134-67-6.mol
• Article Data: 23

Chemical Properties

• Melting Point: 113-114 °C
• Boiling Point: 354.873°C at 760 mmHg
• Flash Point: 168.422°C
• Appearance: /
• Density: 1.462g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Succinimido p-fluorobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Succinimido p-fluorobenzoate(66134-67-6)
• EPA Substance Registry System: Succinimido p-fluorobenzoate(66134-67-6)

Safety Data

• Hazardous Substances Data: 66134-67-6(Hazardous Substances Data)

Usage

Chemical Properties

Colourless solid

InChI:InChI=1/C11H8FNO4/c12-8-3-1-7(2-4-8)11(16)17-13-9(14)5-6-10(13)15/h1-4H,5-6H2

Upstream product

• 456-22-4 4-Fluorobenzoic acid 
• 105832-38-0 O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 
• 74124-79-1 di(succinimido) carbonate 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 201230-82-2 carbon monoxide 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 619-66-9 4-Carboxybenzaldehyde 
• 60444-78-2 succinimidyl 4-formylbenzoate 
• 17592-54-0 2,5-dioxopyrrolidin-1-yl formate 
• 352-34-1 4-fluoro-1-iodobenzene 
• 459-57-4 4-fluorobenzaldehyde 
• 403-43-0 4-fluorobenzoyl chloride 
• 1196658-43-1 (4-((2,5-Dioxopyrrolidin-1-yloxy)carbonyl)phenyl)(thiophen-2-yl)iodonium trifluoroacetate 
• 459-56-3 4-fluorobenzylic alcohol 

Downstream Products

• 1093733-09-5 2-[3-[5-(4-fluoro-benzoylamino)-1-(4-methoxy-benzyloxycarbonyl)-pentyl]-ureido]-pentanedioic acid bis-(4-methoxy-benzyl)ester 
• 217099-16-6 C₃₄H₄₄FN₉O₈ 
• 148671-44-7 3-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-5-amine 
• 277746-28-8 3-(4-fluorophenyl)-5-phenylacetylamino-4-(4-pyridyl)pyrazole 
• 277746-65-3 3-(4-fluorophenyl)-1-methyl-4-(pyridin-4-yl)-1H-pyrazol-5-amine 
• 277747-60-1 5-(4-fluorophenyl)-2-methyl-3-phenylacetylamino-4-(4-pyridyl)pyrazole 
• 1334181-89-3 N-tert-butoxycarbonyl-N'-[6-(4-fluorobenzamido)hexanoyl]-S-methylisothiourea 

Relevant articles and documents

Radical Decarboxylative Carbometalation of Benzoic Acids: A Solution to Aromatic Decarboxylative Fluorination

Abundant aromatic carboxylic acids exist in great structural diversity from nature and synthesis. To date, the synthetically valuable decarboxylative functionalization of benzoic acids is realized mainly by transition-metal-catalyzed decarboxylative cross couplings. However, the high activation barrier for thermal decarboxylative carbometalation that often requires 140 °C reaction temperature limits both the substrate scope as well as the scope of suitable reactions that can sustain such conditions. Numerous reactions, for example, decarboxylative fluorination that is well developed for aliphatic carboxylic acids, are out of reach for the aromatic counterparts with current reaction chemistry. Here, we report a conceptually different approach through a low-barrier photoinduced ligand to metal charge transfer (LMCT)-enabled radical decarboxylative carbometalation strategy, which generates a putative high-valent arylcopper(III) complex, from which versatile facile reductive eliminations can occur. We demonstrate the suitability of our new approach to address previously unrealized general decarboxylative fluorination of benzoic acids.

RADIOACTIVE COMPOUND FOR DIAGNOSIS OF MALIGNANT MELANOMA AND USE THEREOF

The present invention provides a novel radioactive compound for imaging malignant melanoma and a use thereof as a contrast agent for PET imaging.

N-Doped Yellow TiO2 Hollow Sphere-Mediated Visible-Light-Driven Efficient Esterification of Alcohol and N-Hydroxyimides to Active Esters

Herein we report a simple synthetic protocol for N-doped yellow TiO2 (N-TiO2) hollow spheres as an efficient visible-light-active photocatalyst using aqueous titanium peroxocarbonate complex (TPCC) solution as precursor and NH4OH. In the developed strategy, the ammonium ion of TPCC and NH4OH acts as nitrogen source and structure-directing agent. The synthesized N-TiO2 hollow spheres are capable of promoting the synthesis of active esters of N-hydroxyimide and alcohol through simultaneous selective oxidation of alcohol to aldehyde followed by cross-dehydrogenative coupling (CDC) under ambient conditions upon irradiation of visible light. It is possible to develop a novel and cost-effective one-pot strategy for the synthesis of important esters and amides on gram scale using the developed strategy. The catalytic activity of N-TiO2 hollow spheres is much superior to that of other reported N-TiO2 samples as well as TiO2 with varying morphology.