6619-58-5

Basic information

• Product Name: Propanedioic acid, [(4-methylphenyl)methyl]-, diethyl ester
• Synonyms: p-methylbenzyl diethyl malonate;ethyl 2-carbethoxy-3-p-tolyl-propanate;2-(4-methylbenzyl)malonic acid diethyl ester;(4-methyl-benzyl)-malonic acid diethyl ester;2-(4-Methyl-benzyl)-malonic acid diethyl ester;(4-Methyl-benzyl)-malonsaeure-diaethylester;diethyl 2-(4-methylbenzyl)malonate
• CAS NO: 6619-58-5
• Molecular Formula: C15H20O4
• Molecular Weight: 264.321
• Mol File: 6619-58-5.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, [(4-methylphenyl)methyl]-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, [(4-methylphenyl)methyl]-, diethyl ester(6619-58-5)
• EPA Substance Registry System: Propanedioic acid, [(4-methylphenyl)methyl]-, diethyl ester(6619-58-5)

Safety Data

• Hazardous Substances Data: 6619-58-5(Hazardous Substances Data)

Upstream product

• 996-82-7 sodium diethylmalonate 
• 104-82-5 4-Methylbenzyl chloride 
• 104-81-4 4-Methylbenzyl bromide 
• 105-53-3 diethyl malonate 
• 104-87-0 4-methyl-benzaldehyde 
• 104-84-7 para-methylbenzylamine 
• 14111-33-2 diethyl 2-(4-methylbenzylidene)malonate 
• 95-47-6 o-xylene 

Downstream Products

• 109693-05-2 allyl-(4-methyl-benzyl)-malonic acid diethyl ester 
• 502769-40-6 2-[2-(dimethylamino)ethyl]-2-(4-methylbenzyl)malonic acid diethyl ester 
• 94853-59-5 ethyl 2-carbethoxy-2-(p-methylbenzyl)-4-formylbutanoate 
• 1608506-67-7 C₁₃H₁₆ClN₃O 
• 1608506-19-9 C₁₅H₁₉NO₂ 
• 1608506-27-9 C₁₃H₁₇NO 
• 1608506-47-3 C₁₃H₁₆N₄ 
• 1608506-57-5 C₁₃H₁₇N₃O₂ 
• 1608506-11-1 C₁₈H₂₃NO₄ 
• 1110650-46-8 C₂₁H₂₈O₇ 
• 1049796-79-3 diethyl 2-(4-methylbenzyl)-2-(prop-2-ynyl)malonate 
• 94853-61-9 ethyl 2-carbethoxy-2-(p-methylbenzyl)-4,4-ethylenedioxybutanoate 
• 94853-60-8 2-carboxy-2-(p-methylbenzyl)-4,4-ethylenedioxybutanoic acid 
• 107688-59-5 (R)-2-(2-Benzoylsulfanylmethyl-3-p-tolyl-propionylamino)-3-ethylsulfanyl-propionic acid 

Relevant articles and documents

Programmed Sequential Additions to Halogenated Mucononitriles

Dihalomucononitriles were synthesized and their reactivity evaluated to assess their ability to function as linchpin reagents. Bis(2-chloroacrylonitrile) and bis(2-bromoacrylonitrile) were synthesized from 2,1,3-benzothiadiazole and undergo conjugate addition/elimination reactions with both nitrogen (40-95% yield) and carbon nucleophiles (72-93% yield). Secondary amines undergo monosubstitutions, while carbon nucleophiles are added twice. The sequence of addition of the nucleophiles could be controlled to give mixed addition products. The multicomponent coupling products could then be converted to natural product like motifs using intramolecular cyclization reactions.

Aryltrifluoromethylative cyclization of unactivated alkenes by the use of PhICF3Cl under catalyst-free conditions

A concise and catalyst-free aryltrifluoromethylative cyclization of unactivated alkenes has been developed herein. The use of PhICF3Cl as a powerful trifluoromethylating agent allows easy transformations. A set of trifluoroethylated carbocycles and aza-hereocycles were efficiently synthesized in good yield and selectivity. A broad substrate scope, mild reaction conditions, and easy operation would make this method well-suited for applications.

Synthesis and insecticidal activity of mesoionic pyrido[1,2-α]pyrimidinone derivatives containing a neonicotinoid moiety

Mesoionic pyrido[1,2-α]pyrimidinone derivatives containing a neonicotinoid moiety were designed, synthesized, and evaluated for their insecticidal activity. Some of the title compounds showed remarkable insecticidal properties against Aphis craccivora. Compound I13 exhibited satisfactory insecticidal activity against A. craccivora. Meanwhile, label-free proteomics analysis of compound I13 treatment identified a total of 821 proteins. Of these, 35 proteins were up-regulated, whereas 108 proteins were down-regulated. Differential expressions of these proteins reflected a change in cellular structure and metabolism.