6622-04-4

Basic information

• Product Name: 4-oxo-4-(propan-2-ylamino)butanoic acid
• Synonyms: 4-(Isopropylamino)-4-oxobutanoic acid; butanoic acid, 4-[(1-methylethyl)amino]-4-oxo-
• CAS NO: 6622-04-4
• Molecular Formula: C₇H₁₃NO₃
• Molecular Weight: 159.183
• Mol File: 6622-04-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 374.9°C at 760 mmHg
• Flash Point: 180.5°C
• Density: 1.097g/cm³
• Vapor Pressure: 1.19E-06mmHg at 25°C
• Refractive Index: 1.458
• CAS DataBase Reference: 4-oxo-4-(propan-2-ylamino)butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-oxo-4-(propan-2-ylamino)butanoic acid(6622-04-4)
• EPA Substance Registry System: 4-oxo-4-(propan-2-ylamino)butanoic acid(6622-04-4)

Safety Data

• Hazardous Substances Data: 6622-04-4(Hazardous Substances Data)

Upstream product

• 108-30-5 succinic acid anhydride 
• 75-31-0 isopropylamine 

Downstream Products

• 42042-71-7 4-hydroxy-N-isopropylbutan-1-amine 

Relevant articles and documents

Comparison of thermosensitive properties of poly(amidoamine) dendrimers with peripheral N-isopropylamide groups and linear polymers with the same groups

(Graph Presented) The sensitive type: A lower critical solution temperature (LCST) is observed for dendrimers with N-isopropylamide (NIPAM) groups at all chain terminals and for poly(N-isopropylacrylamide) (PNIPAAm; see picture). A much smaller endothermic peak occurs around the LCST for NIPAM-terminated dendrimers. The globular structure of the dendrimers may cause inefficient hydration and dehydration around NIPAM groups below and above the LCST, respectively.

Radical-mediated dehydrative preparation of cyclic imides using (NH4)2S2O8-DMSO: Application to the synthesis of vernakalant

Ammonium persulfate-dimethyl sulfoxide (APS-DMSO) has been developed as an efficient and new dehydrating reagent for a convenient one-pot process for the synthesis of miscellaneous cyclic imides in high yields starting from readily available primary amines and cyclic anhydrides. A plausible radical mechanism involving DMSO has been proposed. The application of this facile one-pot imide forming process has been demonstrated for a practical synthesis of vernakalant.

Syntheses, in vitro antibacterial and antifungal activities of a series of N-alkyl, 1,4-dithiines

A series of dithiines were synthesized by cyclization of 4-(alkylamino)-4-oxobutanoic acids under the action of SOCl2. Their in vitro antibacterial and antifungal activities have been evaluated against reference strains and versus reference compounds. The so-called 'isoimides' 2a, 2b were totally inactive whereas some imides had low MICs for few bacteria and for few fungal microorganisms.