6623-21-8

Basic information

• Product Name: 4,6-DIMETHYLNICOTINONITRILE
• Synonyms: 4,6-DIMETHYLPYRIDINE-3-CARBONITRILE;4,6-DIMETHYLNICOTINONITRILE;4,6-DiMethylintcotinonitrile;3-Cyano-4,6-dimethylpyridine;NSC 54160;EOS-60841
• CAS NO: 6623-21-8
• Molecular Formula: C₈H₈N₂
• Molecular Weight: 132.16
• EINECS: 205-525-8
• Product Categories: Pyridines;cyanide
• Mol File: 6623-21-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 57-58℃
• Boiling Point: 251℃
• Flash Point: 97℃
• Appearance: /
• Density: 1.05
• Vapor Pressure: 0.0214mmHg at 25°C
• Refractive Index: 1.525
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 3.16±0.18(Predicted)
• CAS DataBase Reference: 4,6-DIMETHYLNICOTINONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-DIMETHYLNICOTINONITRILE(6623-21-8)
• EPA Substance Registry System: 4,6-DIMETHYLNICOTINONITRILE(6623-21-8)

Safety Data

• Hazardous Substances Data: 6623-21-8(Hazardous Substances Data)

Usage

General Description

4,6-Dimethylnicotinonitrile is a chemical compound that belongs to the family of pyridines and derivatives. This organic substance features a structure with six carbon atoms in a ring-like shape, comprising two nitrogen atoms and two methyl groups attached to the ring. It is known for its use primarily in research and industrial applications, and it's typically produced and handled by professionals in controlled environments. Exposure to the compound, like any chemical, should be done carefully to prevent potential health risks. Its exact properties and potential utilized are subject to further scientific research.

InChI:InChI=1/C8H8N2/c1-6-3-7(2)10-5-8(6)4-9/h3,5H,1-2H3

Upstream product

• 14237-71-9 2-chloro-4,6-dimethylnicotinonitrile 
• 769-28-8 2-hydroxy-4,6-dimethyl-3-carbonitrile 
• 72456-86-1 S-methyl-4,6-dimethyl-2-thiopyridine-3-carbonitrile 
• 123-54-6 acetylacetone 

Downstream Products

• 13061-58-0 4,6-dimethyl-3-pyridinecarboxamide 
• 22047-86-5 4,6-dimethylpyridine-3-carboxylic acid 
• 7497-35-0 4,6-dimethylpyridine-3-carbonitrile N-oxide 
• 1354036-19-3 N'-(7-amino-2,4-dimethyl-5H-pyrrolo[3,4-b]pyridin-5-ylidene)-4-fluorobenzohydrazide 
• 98489-36-2 1-(4,6-dimethylpyridin-3-yl)methanamine 
• 40217-50-3 angustidine 
• 69971-44-4 Methyl 4,6-Dimethylnicotinate 

Relevant articles and documents

4,6-Dimethylpyridine-2,3-dicarbonitrile and its reaction with N-acylhydrazines

An efficient method has been developed for the synthesis of 4,6-dimethylpyridine-2,3-dicarbonitrile. A study was carried out on the reaction of this compound with N-acylhydrazines to give two structural isomers, namely, N′-(7-amino-2,4-dimethyl-5H-pyrrolo[3,4-b]pyridin-5-ylidene) carbohydrazides and N′-(5-amino-2,4-dimethyl-7H-pyrrolo[3,4-b]pyridin-7- ylidene)carbohydrazides as well as disubstituted N′,N″-(2,4- dimethyl-5H-pyrrolo[3,4-b]pyridine-5,7-diylidene)dicarbohydrazides.

Reductive desulfurization of 3-cyano-2-methylthiopyridines under the action of Raney nickel

The action of Raney nickel on substituted 3-cyano-2-methylthiopyridines was studied. Under conditions of catalytic hydrogenation, the reaction yields a mixture containing the aminosulfide resulting from reduction of the nitrile group with retention of the methylthio group, the nitrile resulting from elimination of the methylthio group, and the amine resulting from both reduction of the nitrile group and elimination of the methylthio group. Treatment of 3-cyano-2-methylthiopyridines with a large amount of Raney nickel under desulfurization conditions induces simultaneous elimination of the methylthio group and reduction of the nitrile group to the aminomethyl group. When reductive desulfurization is carried out in methanol or THF, primary amines are formed, while the reactions in isopropyl or ethyl alcohol give secondary or tertiary amines, which are formed upon alkylation of the amino group with alcohols.