66325-22-2

Basic information

• Product Name: Phosphoric acid, 1-methylpropyl diphenyl ester
• CAS NO: 66325-22-2
• Molecular Formula: C16H19O4P
• Molecular Weight: 306.298
• Mol File: 66325-22-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Phosphoric acid, 1-methylpropyl diphenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphoric acid, 1-methylpropyl diphenyl ester(66325-22-2)
• EPA Substance Registry System: Phosphoric acid, 1-methylpropyl diphenyl ester(66325-22-2)

Safety Data

• Hazardous Substances Data: 66325-22-2(Hazardous Substances Data)

Upstream product

• 2524-64-3 chlorophosphoric acid diphenyl ester 
• 78-92-2 iso-butanol 
• 449813-82-5 3-(diphenylphosphono)-2-(N-cyanoimino)thiazolidine 
• 72305-35-2 diphenyl (4,6-dimethyl-2-pyrimidyl) phosphate 
• 78605-38-6 Diphenyl 2-oxo-3-oxazolinylphosphonate 
• 108-95-2 phenol 
• 681035-22-3 (2-oxo-5,5-diphenyl-oxazolidin-3-yl)-phosphonic acid diphenyl ester 

Relevant articles and documents

Substitution- and elimination-free phosphorylation of functionalized alcohols catalyzed by oxidomolybdenum tetrachloride

Among 14 oxidometallic species examined for catalytic phosphorylation of the tested alcohols, oxidomolybdenum tetrachloride (MoOCl4) was found to be the most efficient with a negligible background reaction mediated by triethylamine (Et3N). The new catalytic protocol can be applied to the chemoselective phosphorylations of primary, secondary and tertiary alcohols as well as the substitution-free phosphorylations of allylic, propargylic, and benzylic alcohols. Functionalized alcohols bearing acetonide, tetrahydropyranyl ether, tert-butyldimethylsilyl ether, or ester group are also amenable to the new catalytic protocol. The most difficult scenarios involve substitution-free phosphorylations of 1-phenylethanol and 1-(2-naphthyl)ethanol which can be effected in 95 and 90% yields, respectively. ESI-MS, IR, 1H, and 31P NMR spectroscopic analyses of the reaction progress suggest the intermediacy of an alkoxyoxidomolybdenum trichloride-triethylamine adduct such as [(RO)Mo(O)Cl3-Et3N] to be responsible for the catalytic turnover.

N-Phosphoryl oxazolidinones as effective phosphorylating agents

A number of N-phosphoryl oxazolidinones have been prepared and evaluated, the best being 5,5-diphenyl oxazolidinones, the utility of which was demonstrated in the phosphorylation of a number of representative primary, secondary, tertiary, and phenolic alcohols.

Reaction of pyrimidyl esters of some phosphorus acids with isomeric butyl alcohols

A series of pyrimidyl esters of some phosphorus acids was prepared with the purpose of investigation of their reaction with isomeric butyl alcohols. According to31P NMR data, the obtained phosphates all are capable of phosphorylating isomeric butyl alcohols. The reactions with diphenyl (4-oxo-3,4-dihydro-2-pyrimidyl) phosphate and diphenyl (2-pyrimidyl) phosphate occur in quantitative yield under mild conditions, and the reactions with diphenyl (4,6-dimethyl-2-pyrimidyl) phosphate and dibutyl (4,6-dimethyl-2-pyrimidyl) phosphate require severe conditions to occur. In the latter two cases, certain reaction selectivity was observed, depending on the nature of the solvent and some other factors. Pyrimidyl esters of sulfur-containing phosphorus acids do not react with isomeric butyl alcohols under the studied conditions.