66346-59-6Relevant articles and documents
N-Oxide heterocycles and imidazoles replacing ring D of calanolides against Mycobacterium tuberculosis
Liu, Zi-Jie,Guo, Xiao-Yong,Liu, Gang
, p. 51 - 54 (2016)
We have explored the chemistry of N-oxide heterocycles and imidazoles replacing ring D of the natural product (+)-calanolide A, and have synthesized 12 new analogues, two of which were active against both R Mtb and NR Mtb with MIC values of 12.5 μg/mL, which would lead to further optimization for more potent anti-TB candidates.
1-Nicotinoylbenzotriazole: A Convenient Tool for Site-Selective Protection of 5,7-Dihydroxycoumarins
Charushin, Valery N.,Chupakhin, Oleg N.,Fatykhov, Ramil F.,Inyutina, Anna K.,Kartsev, Victor G.,Khalymbadzha, Igor A.,Slepukhin, Pavel A.
, p. 3617 - 3624 (2019/09/30)
1-Nicotinoylbenzotriazole (NicBt) was uncovered as an efficient protecting agent for the site-selective acylation of resorcinol-type phenolic groups with almost equal reactivity. The use of NicBt allows selective protection of the 7-OH group in 5,7-dihydr
TETRIACYCLODIPYRANYL COUMARINS AND THE ANTI-HIV AND ANTI-TUBERCULOSIS USES THEREOF
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Page/Page column 31, (2010/08/18)
The present invention relates to tctracyclodipyrano-coumarin compounds of general formula (I), wherein the substituents are defined herein. These compounds exihibit dual biological activities of anti human immunodeficiency virus type 1 (HIV-1) infection a