6635-27-4

Basic information

• Product Name: ethyl (2E)-3-[4-(acetyloxy)-3-methoxyphenyl]prop-2-enoate
• CAS NO: 6635-27-4
• Molecular Formula: C₁₄H₁₆O₅
• Molecular Weight: 264.2738
• Mol File: 6635-27-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 362.4°C at 760 mmHg
• Flash Point: 158.4°C
• Density: 1.156g/cm³
• Vapor Pressure: 1.94E-05mmHg at 25°C
• Refractive Index: 1.535
• CAS DataBase Reference: ethyl (2E)-3-[4-(acetyloxy)-3-methoxyphenyl]prop-2-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (2E)-3-[4-(acetyloxy)-3-methoxyphenyl]prop-2-enoate(6635-27-4)
• EPA Substance Registry System: ethyl (2E)-3-[4-(acetyloxy)-3-methoxyphenyl]prop-2-enoate(6635-27-4)

Safety Data

• Hazardous Substances Data: 6635-27-4(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 2596-47-6 (E)-3-(4-acetoxy-3-methoxyphenyl)acrylic acid 
• 881-68-5 vanillin acetate 
• 1530-45-6 (carbethoxymethyl)triphenylphosphonium bromide 
• 1135-24-6 (E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid 
• 4046-02-0 ethyl 4-hydroxy-3-methoxycinnamate 
• 108-24-7 acetic anhydride 
• 1071-46-1 hydrogen ethyl malonate 

Downstream Products

• 5279-80-1 ethyl 2-(3,4-dimethoxyphenyl)cyclopropanecarboxylate 
• 4046-02-0 ethyl 4-hydroxy-3-methoxycinnamate 
• 458-35-5 coniferal alcohol 

Relevant articles and documents

Structural Fine-Tuning of Desmuramylpeptide NOD2 Agonists Defines Their in Vivo Adjuvant Activity

We report on the design, synthesis, and biological evaluation of a series of nucleotide-binding oligomerization-domain-containing protein 2 (NOD2) desmuramylpeptide agonists with improved in vitro and in vivo adjuvant properties. We identified two promising compounds: 68, a potent nanomolar in vitro NOD2 agonist, and the more lipophilic 75, which shows superior adjuvant activity in vivo. Both compounds had immunostimulatory effects on peripheral blood mononuclear cells at the protein and transcriptional levels, and augmented dendritic-cell-mediated activation of T cells, while 75 additionally enhanced the cytotoxic activity of peripheral blood mononuclear cells against malignant cells. The C18 lipophilic tail of 75 is identified as a pivotal structural element that confers in vivo adjuvant activity in conjunction with a liposomal delivery system. Accordingly, liposome-encapsulated 75 showed promising adjuvant activity in mice, surpassing that of muramyl dipeptide, while achieving a more balanced Th1/Th2 immune response, thus highlighting its potential as a vaccine adjuvant.

Preparation method of ferulic acid derivative feed additive and application thereof

The invention discloses a preparation method of a ferulic acid derivative feed additive and application thereof, and relates to the technical field of feed additives. The preparation method comprises the steps that ferulic acid is adopted as raw materials