66399-01-7

Basic information

• Product Name: 4-CHLORO-3-NITROBENZALDEHYDE OXIME
• Synonyms: 4-CHLORO-3-NITROBENZALDEHYDE OXIME;4-CHLORO-3-NITROBENZENECARBALDEHYDE OXIME
• CAS NO: 66399-01-7
• Molecular Formula: C₇H₅ClN₂O₃
• Molecular Weight: 200.58
• Mol File: 66399-01-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 147-150°
• Boiling Point: 321.483 °C at 760 mmHg
• Flash Point: 148.228 °C
• Appearance: /
• Density: 1.504 g/cm³
• Vapor Pressure: 0.000123mmHg at 25°C
• Refractive Index: 1.612
• CAS DataBase Reference: 4-CHLORO-3-NITROBENZALDEHYDE OXIME(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-3-NITROBENZALDEHYDE OXIME(66399-01-7)
• EPA Substance Registry System: 4-CHLORO-3-NITROBENZALDEHYDE OXIME(66399-01-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 66399-01-7(Hazardous Substances Data)

Usage

General Description

4-CHLORO-3-NITROBENZALDEHYDE OXIME is a chemical compound that belongs to the class of nitrobenzaldehyde oximes. It is a pale yellow crystalline solid that is used as an intermediate in the synthesis of various organic compounds. This chemical is known for its use in the production of pharmaceuticals, dyes, and agrochemicals. It is also utilized as a reagent in organic synthesis and in the production of fine chemicals. Additionally, 4-CHLORO-3-NITROBENZALDEHYDE OXIME is used as a raw material in the manufacturing of rubber chemicals, antioxidants, and corrosion inhibitors. It is important to handle this chemical with caution as it can be hazardous if not used properly.

InChI:InChI=1/C7H5ClN2O3/c8-6-2-1-5(4-9-11)3-7(6)10(12)13/h1-4,11H/b9-4-

Upstream product

• 16588-34-4 4-chloro-3-nitro-benzaldehyde 
• 79-24-3 Nitroethane 

Downstream Products

• 1071927-86-0 N-(3-(5-(3,5-dichlorophenyl)-4,5-dihydro-5-trifluoromethyl-isoxazol-3-yl)-6-chloro-phenyl)-3,3,3-trifluoro-propanamide 
• 1071927-89-3 N-(5-(5-(3,5-dichlorophenyl)-4,5-dihydro-5-trifluoromethyl-3-isoxazolyl)-2-chloro-phenyl)-O-methyl-carbamate 
• 1237587-32-4 N′-{5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-chlorophenyl}nicotinohydrazide 
• 1237587-74-4 C₂₃H₁₆Cl₃F₃N₄OS 
• 1237587-73-3 C₂₃H₂₂Cl₃F₃N₄OS 
• 1237587-72-2 C₂₃H₂₂Cl₃F₃N₄O₂ 
• 1237587-71-1 C₂₃H₁₅Cl₃F₃N₅O₄ 
• 1237587-70-0 C₂₄H₁₈Cl₃F₃N₄O₃ 
• 1237587-69-7 C₂₃H₁₆Cl₃F₃N₄O₂ 
• 1237587-68-6 C₂₆H₁₉Cl₃F₃N₃O₄ 
• 1237587-67-5 C₂₇H₁₈Cl₃F₆N₃O₃ 
• 1237587-66-4 C₂₇H₁₉Cl₃F₃N₃O₃ 
• 1237587-65-3 C₂₅H₁₇Cl₃F₃N₃O₃ 
• 1237587-64-2 C₂₂H₁₆Cl₃F₆N₃O₃ 

Relevant articles and documents

Nonbenzamidine isoxazoline derivatives as factor Xa inhibitors

Factor Xa (fXa) is an important serine protease in the blood coagulation cascade. Inhibition of fXa has emerged as an attractive target for potential therapeutic applications in the treatments of both arterial and venous thrombosis. Herein, we describe a series of non-benzamidine isoxazoline derivatives as fXa inhibitors. The chloroaniline group was found to be the most potent benzamidine mimic in this series. Chloroaniline 1 (ST368) has a Ki value of 1.5 nM against fXa and is highly selective for fXa relative to thrombin and trypsin.

HENRY CONDENSATION UNDER HIGH PRESSURE. 2. EFFECT OF AROMATIC ALDEHYDE TYPE AND PRESSURE ON THE YIELD OF ω-NITROSTYRENES AND SECONDARY PROCESSES

Condensation of aromatic aldehydes (I)-(XX) with EtNO2 and n-PrNO2 in AcOH in the presence of AcONH4 or i-BuNH2 gives primarily ω-nitrostyrenes (Ia, b) - (XXa, b) and small quantities of nitriles (Ic) - (XXc), oximes (Id) - (XXd), and ketones (Ie, f) - (XXe, f).The yields of (Ia, b) - (XXa, b) at P = 1 atm are higher for acceptor substitutents on the aromatic ring whereas at P = 10 kbar, they are higher for donor substituents.High pressures suppress the formation of (Ic-f) - (XXc-f) and the Z-isomers of (Ia, b) - (XXa, b).The high pressure technique is especially useful in the preparation of donor-substituted (Ia, b) - (XXa, b) which are intermediates in the synthesis of the psychotropic β-phenylethylamines.