66422-10-4Relevant articles and documents
New compounds with anticancer agent
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Paragraph 0038; 0057; 0058, (2017/09/21)
Provided are: a novel compound that has excellent cytotoxicity; and an antitumor agent. Also provided is a method for simply producing the novel compound. Provided are: a compound represented by formula (I); and an antitumor agent which contains the compound as an active ingredient. The compound represented by formula (I) is produced by a two-step process using compounds represented by formulae (II) and (III) as starting materials. In formulae (I), (III), (IV) and (V), each of R1, R2, Ra and Rb represents an alkyl group or the like; R3 represents a leaving group; n represents an integer of 1-4; and two -(CH2)n-NR1R2 groups represent the same substituent.
Practical synthesis of FEt-penta-cyclofenil and its derivatives for potential PET imaging
Zhu, Hua,Huang, Liliang,Xu, Xiaoping,Shen, Yu-Mei
experimental part, p. 3322 - 3331 (2011/01/04)
Generally, FEt-penta-cyclofenil and its derivatives have greater relative binding affinity to estradiol receptors than estradiol. (4-Fluoroethoxyphenyl)- (4'-hydroxyphenyl) methylenecyclopentane and its derivatives were synthesized for potential radioactive image agents, and their structures were characterized by ultraviolet, infrared, 1H NMR, 19F NMR, and high-resolution mass spectrometry. Copyright
Convenient one-pot synthesis of 2,2-bis-(4-hydroxyphenyl)-cyclopentanone
Jai, Woong Seo,Hee, Jun Kim,Byoung, Se Lee,Katzenellenbogen, John A.,Dae, Yoon Chi
, p. 715 - 718 (2008/09/18)
(Chemical Equation Presented) 2,2-Bis-(4-hydroxyphenyl)-cyclopentanone (3a) was unexpectedly obtained in 76% yield from a reductive coupling reaction of 4,4′-dihydroxybenzophenone (1a) and cyclobutanone with TiCl4 and Zn. Further optimization showed that catechol as an external ligand and a hydroxy group on benzophenone facilitated the generation of a quinonemethide (intermediate II) that is involved in the pinacol-type rearrangement of intermediate I to give the rearranged product.