66510-99-4

Basic information

• Product Name: (6β)-3-(1-Methyl-1H-tetrazole-5-ylthiomethyl)-7α-amino-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]octa-2-ene-2-carboxylic acid benzhydryl ester
• Synonyms: (6R,7R)-7-Amino-7-methoxy-3-[(1-methyl-1H-tetrazol-5-ylthio)methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester;(6β)-3-(1-Methyl-1H-tetrazole-5-ylthiomethyl)-7α-amino-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]octa-2-ene-2-carboxylic acid benzhydryl ester;LataMoxef SodiuM InterMediate 2;(6R,7R)-Benzhydryl 7-amino-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)-thio)methyl)-8-oxo-5-oxa-1-a;(6R,7R)-Benzhydryl 7-amino-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)-thio)methyl)-8-oxo-5-oxa-;Intermediate 2 of Latamoxef Sodium;RJBJKWDIIMRLDA-ZBQDIEFISA-N
• CAS NO: 66510-99-4
• Molecular Formula: C₂₄H₂₄N₆O₅S
• Molecular Weight: 508.56
• EINECS: 1533716-785-6
• Mol File: 66510-99-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 723.6±70.0 °C(Predicted)
• Appearance: /
• Density: 1.49
• Storage Temp.: 2-8°C
• PKA: 2.85±0.60(Predicted)
• CAS DataBase Reference: (6β)-3-(1-Methyl-1H-tetrazole-5-ylthiomethyl)-7α-amino-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]octa-2-ene-2-carboxylic acid benzhydryl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (6β)-3-(1-Methyl-1H-tetrazole-5-ylthiomethyl)-7α-amino-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]octa-2-ene-2-carboxylic acid benzhydryl ester(66510-99-4)
• EPA Substance Registry System: (6β)-3-(1-Methyl-1H-tetrazole-5-ylthiomethyl)-7α-amino-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]octa-2-ene-2-carboxylic acid benzhydryl ester(66510-99-4)

Safety Data

• Hazardous Substances Data: 66510-99-4(Hazardous Substances Data)

Usage

General Description

The chemical "(6β)-3-(1-Methyl-1H-tetrazole-5-ylthiomethyl)-7α-amino-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]octa-2-ene-2-carboxylic acid benzhydryl ester" is a complex compound with multiple functional groups. It contains a tetrazole ring, an amino group, a methoxy group, and a carboxylic acid moiety, among others. The benzhydryl ester group is also present in the compound. Overall, this chemical structure suggests potential pharmacological activity, possibly as an antibiotic, due to the presence of the β-lactam core and the amino group. However, further research and evaluation are necessary to determine its specific properties and potential applications.

Upstream product

• 66429-65-0 (6R)-7t-amino-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-(6rH)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 96855-19-5 7-amino-3-chloromethyl-1-oxa-3-cephem-4-carboxylic acid diphenyl ester 
• 51138-06-8 sodium 1-methyl-1H-tetrazole-5-thiolate 
• 68402-51-7 (6R,7R)-7-Benzoylamino-3-chloromethyl-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzyl ester 
• 68402-81-3 diphenylmethyl 7β-benzamido-7α-methoxy-3-<<(1-methyl-1H-yetrazol-5-yl)thio>methyl>-1-oxadethia-3-cephem-4-carboxylate 
• 66364-50-9 diphenylmethyl 7β-(phenylacetamido)-7α-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-1-oxadethia-3-cephem-4-carboxylate 

Downstream Products

• 70653-54-2 C₄₁H₃₈N₆O₁₀S 
• 76858-80-5 latamoxef disodium 
• 73955-50-7 (6R)-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-7t-(2-oxo-3-phenyl-propyl)-(6rH)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 73955-51-8 (6R)-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-7t-(2-oxo-3-phenyl-propyl)-(6rH)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 75007-70-4 decarboxy-moxalactam 
• 318730-57-3 (6R,7R)-7-Methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-7-(2-phenoxy-benzoylamino)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-benzhydryloxycarbonyl-benzyl ester 
• 318730-53-9 (6R,7R)-7-(2-Isobutoxy-benzoylamino)-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-benzhydryloxycarbonyl-benzyl ester 
• 318730-43-7 (6R,7R)-7-Methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-7-(2-propoxy-benzoylamino)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-benzhydryloxycarbonyl-benzyl ester 
• 318730-37-9 (6R,7R)-7-(2-Ethoxy-benzoylamino)-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-benzhydryloxycarbonyl-benzyl ester 
• 318730-48-2 (6R,7R)-7-(2-Isopropoxy-benzoylamino)-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-benzhydryloxycarbonyl-benzyl ester 
• 318730-31-3 (6R,7R)-7-Methoxy-7-(2-methoxy-benzoylamino)-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-benzhydryloxycarbonyl-benzyl ester 

Relevant articles and documents

Synthesis method of cefamoxef sodium

The invention relates to a synthesis method of latamoxef sodium. The synthesis method specifically comprises the following steps: reacting an oxygen cephalosporin mother nucleus 1 with 1-methyl-5-mercaptotetrazole sodium salt to obtain a compound 2, carrying out deprotection to obtain a compound 3, adding methoxyl and a 7-site side chain on the compound 3 to obtain a compound 5, and then, carryingout final deprotection on the compound 5 to obtain high-purity latamoxef sodium. The method provided by the invention is high in yield, mild in condition and environment-friendly; enzyme is used fordeprotection and condensation reaction, so that high-toxicity and high-corrosivity reagents are avoided; and the high-purity latamoxef sodium is obtained at a high yield.

7 β-amino -7 α-methoxy-3-cephem compound preparation method

The invention relates to a preparation method of a medical raw material 7beta-amino-7lapha-methoxy-3-cephem compound. Methods in prior arts have the problems of more steps and low yield. According to the 7beta-amino-7lapha-methoxy-3-cephem compound preparation method provided by the invention, a beta-lactam compound is adopted as a raw material, and is subjected to a reaction with bis(trichloromethyl)carbonate under the existence of an organic alkali, such that a iminochloride-beta-lactam compound is produced; methanol is added for alcoholysis, such that the 7beta-amino-7lapha-methoxy-3-cephem compound is produced. The method provided by the invention has the advantages of mild and easy-to-control reaction conditions, high yield, no product of 7alpha-methoxy-7beta-amino-3-cephem compound isomer, and easy separation. With the method, the 7beta-amino-7lapha-methoxy-3-cephem compound product with ultrahigh purity can be obtained.

Stereochemistry in borohydride reduction of 7-imino-cephems: An improved method for conversion of the 7α-amino- 1-oxa(thia)cephems into the 7β-amino isomers

Sodium cyanoborohydride in methanol containing hydrogen chloride (pH ~3) proved to be an excellent reagent system for smooth and highly stereo-selective reduction of the 7-imino-1-oxa(thia)cephems 6 or their equivalent 7-methoxy amines 8 to the correspond