66553-15-9

Basic information

• Product Name: 2,3-dimethylbutane-1,2-diol
• Synonyms: 2,3-dimethylbutane-1,2-diol;2,3-Dimethyl-1,2-butanediol
• CAS NO: 66553-15-9
• Molecular Formula: C₆H₁₄O₂
• Molecular Weight: 118.17416
• EINECS: 266-403-0
• Mol File: 66553-15-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 26.38°C (estimate)
• Boiling Point: 221.7°C (rough estimate)
• Flash Point: 77 °C
• Appearance: /
• Density: 0.9843 (rough estimate)
• Vapor Pressure: 0.204mmHg at 25°C
• Refractive Index: 1.4470
• CAS DataBase Reference: 2,3-dimethylbutane-1,2-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dimethylbutane-1,2-diol(66553-15-9)
• EPA Substance Registry System: 2,3-dimethylbutane-1,2-diol(66553-15-9)

Safety Data

• Hazardous Substances Data: 66553-15-9(Hazardous Substances Data)

Usage

General Description

2,3-dimethylbutane-1,2-diol, also known as pinacolone, is a chemical compound with the molecular formula C6H14O2. It is a colorless liquid with a faint, sweet odor. 2,3-dimethylbutane-1,2-diol is commonly used as a solvent in various chemical reactions and is also used in the production of pharmaceuticals and other organic compounds. It is considered to be relatively low in toxicity and is not known to be harmful to the environment. 2,3-dimethylbutane-1,2-diol is also used as a building block for the synthesis of other organic compounds and is an important intermediate in organic chemistry.

InChI:InChI=1/C6H14O2/c1-5(2)6(3,8)4-7/h5,7-8H,4H2,1-3H3

Upstream product

• 98560-72-6 2-hydroxy-2,3-dimethyl-butyric acid ethyl ester 
• 66461-67-4 2-hydroxy-2,3-dimethyl-butyric acid amide 
• 594-52-5 2-bromo-2,3-dimethylbutane 
• 4111-10-8 (+/-)-2-hydroxy-2,3-dimethylbutanenitrile 
• 5396-58-7 2-methyl-2,3-butanediol 
• 563-80-4 3-methyl-butan-2-one 
• 64-17-5 ethanol 
• 129257-01-8 2,3-dimethyl-but-3-ene-1,2-diol 
• 3639-20-1 (+/-)-2-hydroxy-2,3-dimethylbutanoic acid 
• 563-78-0 2,3-Dimethyl-1-butene 

Downstream Products

• 49642-48-0 2,3-dimethylbutanal 
• 743477-22-7 1-hydroxymethyl-1,2-dimethylpropyl ethylcarbamate 
• 132561-72-9 2,3-Dimethyl-1-(tosyloxy)-2-butanediol 

Relevant articles and documents

A facile synthesis of vicinal cis-diols from olefins catalyzed by in situ generated MnxOy nanoaggregates

A novel protocol for the practical and green synthesis of vicinal cis-diols from 10.0 mmol olefins by using 5.0 mmol KMnO4 as oxidant and 30.0 mmol H2O2 as co-oxidant is reported. The presented procedure is easy to carry out and enables the direct transformation of linear and cyclic alkenes to the corresponding vicinal cis-diols. The synthesis of vicinal cis-diols by dihydroxylation of olefins with a KMnO4/H2O2 system was catalyzed by in situ generated MnxOy nanoaggregates. The use of H2O2 as a co-oxidant is the key for the protocol to synthesize vicinal cis-diols in high yields, because it assists the oxidation of MnxOy nanoaggregates, which have an active role in the oxidation reaction medium.

Rh-catalyzed enantioselective diboration of simple alkenes: Reaction development and substrate scope

The rhodium-catalyzed reaction between bis(catecholato)diboron and simple alkenes results in the syn addition of the diboron across the alkene. The resulting 1,2-bis(boronate) is subsequently oxidized to provide the 1,2-diol. In the presence of enantiomerically enriched Quinap ligand, high enantioselection in the diboration can be achieved. The reaction is highly selective for trans- and trisubstituted alkenes and can be selective for some monosubstituted alkenes as well. The development of this reaction is described as is the substrate scope and experiments that are informative about the reaction mechanism and competing pathways.

Treatment of neurodegenerative diseases

Disclosed are methods for increasing the differentiation of mammalian neuronal cells for purposes of treating neurodegenerative diseases or nerve damage by administration of various compounds including alcohols, diols and/or triols and their analogues.