66639-67-6 Usage
Description
1,2-Di(5-amidino-2-benzofuranyl)ethane is a chemical compound with the molecular formula C22H18N4O2. It is an amidine derivative that features two benzofuran rings, each attached to an amidine group. This unique structure and the presence of amidine groups give it potential applications in organic synthesis and pharmaceuticals, as it may serve as a building block for developing new drugs or materials and interact with biological systems.
Uses
Used in Organic Synthesis:
1,2-Di(5-amidino-2-benzofuranyl)ethane is used as a building block in organic synthesis for the development of new compounds and materials. Its unique structure and amidine groups provide versatility in chemical reactions and the potential for creating novel molecules with specific properties.
Used in Pharmaceutical Industry:
1,2-Di(5-amidino-2-benzofuranyl)ethane is used as a precursor in the pharmaceutical industry for the development of new drugs. Its amidine groups may allow it to interact with biological systems, making it a promising candidate for the creation of therapeutic agents that can target specific biological pathways or receptors.
Further research and testing are necessary to fully understand the potential uses and effects of 1,2-Di(5-amidino-2-benzofuranyl)ethane, as its applications in various fields are still being explored.
Check Digit Verification of cas no
The CAS Registry Mumber 66639-67-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,6,3 and 9 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 66639-67:
(7*6)+(6*6)+(5*6)+(4*3)+(3*9)+(2*6)+(1*7)=166
166 % 10 = 6
So 66639-67-6 is a valid CAS Registry Number.
66639-67-6Relevant articles and documents
Synthesis and in vitro antiprotozoal activity of bisbenzofuran cations
Bakunova, Svetlana M.,Bakunov, Stanislav A.,Wenzler, Tanja,Barszcz, Todd,Werbovetz, Karl A.,Brun, Reto,Hall, James Edwin,Tidwell, Richard R.
, p. 5807 - 5823 (2007)
Forty three cationic bisbenzofurans were synthesized either by interaction of o-hydroxyaldehydes with α-halogenated ketones followed by intramolecular ring closure or by a copper- or palladium-mediated heteroannulation of substituted o-iodophenols with terminal acetylenes. In vitro antiprotozoal activities of compounds 1-43 against Trypanosoma brucei rhodesiense, Plasmodium falciparum, and Leishmania donovani and cytotoxicity against mammalian cells were influenced by the position and the type of cationic substituents as well as the length of the carbon linker between aromatic moieties. One bisamidine displayed an antitrypanosomal efficacy comparable to that of pentamidine and melarsoprol. Twenty two compounds were more potent than pentamidine and seven dications were more effective than artemisinin against P. falciparum. Eight bisbenzofurans displayed activity against L. donovani superior to that of pentamidine. Overall, bisamidines connected by two-carbon linkers exhibited the highest efficacies against T. b. rhodesiense, P. falciparum, and L. donovani.
