66698-28-0

Basic information

• Product Name: 1-(4-BROMOPHENYL)PIPERAZINE
• Synonyms: 1-(4-BROMOPHENYL)PIPERAZINE;1-(4-BROMO-PHENYL)-PIPERAZINE DIHYDROCHLORIDE
• CAS NO: 66698-28-0
• Molecular Formula: C₁₀H₁₃BrN₂
• Molecular Weight: 241.13
• Product Categories: Heterocycles;pharmacetical;Piperaizine
• Mol File: 66698-28-0.mol
• Article Data: 13

Chemical Properties

• Melting Point: 93-94°C
• Boiling Point: 353.3 °C at 760 mmHg
• Flash Point: 167.5 °C
• Appearance: /
• Density: 1.386 g/cm³
• Vapor Pressure: 3.62E-05mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: 2-8°C
• PKA: 8.88±0.10(Predicted)
• CAS DataBase Reference: 1-(4-BROMOPHENYL)PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BROMOPHENYL)PIPERAZINE(66698-28-0)
• EPA Substance Registry System: 1-(4-BROMOPHENYL)PIPERAZINE(66698-28-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22
• WGK Germany: 1
• Hazardous Substances Data: 66698-28-0(Hazardous Substances Data)

Usage

General Description

1-(4-Bromophenyl)piperazine is a chemical compound with the molecular formula C10H13BrN2. It is a derivative of piperazine and contains a bromine atom attached to the phenyl ring. The compound is commonly used as a precursor or intermediate in the synthesis of various pharmaceuticals and organic compounds. It has also been studied for its potential pharmacological effects, particularly its activity as a serotonin receptor agonist. Additionally, 1-(4-Bromophenyl)piperazine has been investigated for its potential use in the treatment of various neurological and psychological disorders. However, it is important to note that this compound can be hazardous if mishandled, and proper safety precautions should be taken when working with it.

InChI:InChI=1/C10H13BrN2/c11-9-1-3-10(4-2-9)13-7-5-12-6-8-13/h1-4,12H,5-8H2

Upstream product

• 92-54-6 4-phenyl-1-piperazine 
• 334-22-5 N,N-bis(chloro-2-ethyl)amine 
• 106-40-1 4-bromo-aniline 
• 589-87-7 1,4-bromoiodobenzene 
• 352437-09-3 tert-butyl 4-(4-bromophenyl)piperazine-1-carboxylate 
• 110-85-0 piperazine 
• 106-37-6 1.4-dibromobenzene 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 43204-63-3 bis(2-bromoethyl)amine hydrobromide 

Downstream Products

• 678996-43-5 1-acetyl-4-(4-bromo-phenyl)-piperazine 
• 116290-18-7 1-phenoxy-4-[4-(4-bromophenyl)-1-piperazinyl]-2-butanol 
• 127625-41-6 2-<3-<4-(4-bromophenyl)-1-piperazinyl>propyl>-2H-naphth<1,8-cd>isothiazole 1,1-dioxide 
• 127780-55-6 3-(4-{3-[4-(4-Bromo-phenyl)-piperazin-1-yl]-2-hydroxy-propoxy}-phenyl)-2-methyl-3H-quinazolin-4-one 
• 357647-98-4 1-(4-bromophenyl)-4-(methylsulfonyl)piperazine 
• 581811-67-8 4-(4-bromophenyl)-N-5-isoquinolinyl-1-piperazinecarboxamide 
• 130307-08-3 1-bromo-4-(4-methyl-1-piperazinyl)benzene 
• 1416217-69-0 1-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-yl)4-(4-bromophenyl)piperazine 
• 1416217-83-8 4'-[4-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-yl)-piperazin-1-yl]-[1,1'-biphenyl]-4-ol 
• 1416217-84-9 4'-[4-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-yl)piperazin-1-yl]-3-chloro-[1,1'-biphenyl]-4-ol 
• 1416217-85-0 4-(4-(4-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-yl)-piperazin-1-yl)phenyl)pyrimidine 
• 1416217-86-1 5-(4-(4-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-yl)-piperazin-1-yl)phenyl)-1H-indole 
• 1416217-75-8 1-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-yl)-(1-[1,1'-biphenyl]-4-yl)piperazine 
• 1416217-76-9 C₂₉H₂₈N₆O₂ 

Relevant articles and documents

MONOACYLGLYCEROL LIPASE INHIBITORS

Provided are compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof: Also provided are compositions comprising compounds of formula (I). The compounds and compositions are also provided for use as medicaments, for example as medicaments useful in the treatment of a condition modulated by monoacylglycerol lipase (MAGL). Also provided are the use of compounds and compositions for the inhibition of monoacylglycerol lipase (MAGL).

COMPOUND SIMULTANEOUSLY INHIBITING LSD1 AND HDAC TARGETS AND APPLICATION THEREOF

A compound having a general structural formula as shown in Formula I: X-AB-Y (Formula I); in the above Formula I, X is selected from any one of -CO2H, -CONHZ, -CH=CH-CO2H, -CH=CH-CONHZ, wherein Z is selected from any one of substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted aryl, and hydroxyl; Y = -NR1R2, wherein NR1R2 is a substituted or unsubstituted 3- to 9-membered nitrogen-containing heterocycloalkyl; A and B are each independently selected from substituted or unsubstituted phenylene, substituted or unsubstituted azaphenylene. The compound or corresponding pharmaceutical salt thereof can inhibit LSD1 and HDAC target proteins at the same time, thus inhibit the proliferation of many kinds of tumor cells and have good antitumor effect.

Ni-Catalyzed Reductive Cyanation of Aryl Halides and Phenol Derivatives via Transnitrilation

Herein, we report a Ni-catalyzed reductive coupling for the synthesis of benzonitriles from aryl (pseudo)halides and an electrophilic cyanating reagent, 2-methyl-2-phenyl malononitrile (MPMN). MPMN is a bench-stable, carbon-bound electrophilic CN reagent that does not release cyanide under the reaction conditions. A variety of medicinally relevant benzonitriles can be made in good yields. Addition of NaBr to the reaction mixture allows for the use of more challenging aryl electrophiles such as aryl chlorides, tosylates, and triflates. Mechanistic investigations suggest that NaBr plays a role in facilitating oxidative addition with these substrates.