6672-69-1Relevant articles and documents
Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines
France, Scott P.,Aleku, Godwin A.,Sharma, Mahima,Mangas-Sanchez, Juan,Howard, Roger M.,Steflik, Jeremy,Kumar, Rajesh,Adams, Ralph W.,Slabu, Iustina,Crook, Robert,Grogan, Gideon,Wallace, Timothy W.,Turner, Nicholas J.
supporting information, p. 15589 - 15593 (2017/12/02)
Biocatalytic retrosynthetic analysis of dibenz[c,e]azepines has highlighted the use of imine reductase (IRED) and ω-transaminase (ω-TA) biocatalysts to establish the key stereocentres of these molecules. Several enantiocomplementary IREDs were identified
Asymmetric activation of tropos catalysts in the stereoselective catalytic conjugate additions of R2Zn to α,β-enones: An efficient synthesis of (-)-muscone
Scafato, Patrizia,Cunsolo, Giovanni,Labano, Stefania,Rosini, Carlo
, p. 8801 - 8806 (2007/10/03)
The preparation of a new phosphoramidite starting from (R)-BINOL and a biphenylamine is presented. In such a compound the chirality is due only to atropisomerism and this molecule possesses a flexible biphenylamine residue. Therefore it can work as a tropos catalyst. The catalytic efficiency of this new phosphoramidite has been tested in some asymmetric conjugate additions of dialkylzinc reagents to α,β-enones and compared with that of an analogous already known non-tropos ligand. Interestingly, while comparable results were obtained in the addition of ZnEt2 to chalcone and cyclohexenone, in the case of the addition of ZnMe2 to (E)-cyclopentadec-2-en-1-one, the new ligand provides (-)-muscone, a valuable ingredient of the perfume industry, in 84% ee, while the non-tropos ligand gives a much lower (57%) ee value. Graphical Abstract
A facile synthesis of 6-alkyl-6,7-dihydro-5H-dibenz[c,e]azepines: Potent hypolipidemics
Akula,Kabalka
, p. 3901 - 3906 (2007/10/03)
6-Alkyl-6,7-dihydro-5H-dibenz[c,e]azepines were synthesized in two steps in 63-88% overall yield by utilizing an efficient borane-tetrahydrofuran reduction of imides.