6681-13-6

Basic information

• Product Name: HERNANDEZINE
• Synonyms: (1S)-5,6,6',7,12-Pentamethoxy-2,2'-dimethylberbaman;[1S,(+)]-5,6,6',7,12-Pentamethoxy-2,2'-dimethylberbaman;ThalicsiMine;ThalixiMine;HERNDEZINE
• CAS NO: 6681-13-6
• Molecular Formula: C₃₉H₄₄N₂O₇
• Molecular Weight: 654.799
• Mol File: 6681-13-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 192-193℃
• Boiling Point: 732.8±60.0 °C(Predicted)
• Appearance: /
• Density: 1.175±0.06 g/cm3 (20 ºC 760 Torr)
• PKA: 7.69±0.20(Predicted)
• CAS DataBase Reference: HERNANDEZINE(CAS DataBase Reference)
• NIST Chemistry Reference: HERNANDEZINE(6681-13-6)
• EPA Substance Registry System: HERNANDEZINE(6681-13-6)

Safety Data

• Hazardous Substances Data: 6681-13-6(Hazardous Substances Data)

Usage

Uses

Hernandezine is a novel anticancer AMPK activator identified as a major major active constituent of Thalictrum Ranunculaceae.

Upstream product

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Relevant articles and documents

Hernandezine salt and preparation method thereof

The invention discloses a hernandezine salt prepared from hernandezine and an acid, wherein the acid is at least one of hydrochloric acid, hydrobromic acid, carbonic acid, sulfuric acid, phosphoric acid, nitric acid, maleic acid, fumaric acid, succinic acid, oxalic acid, trifluoroacetic acid, tartaric acid, ascorbic acid, N-benzoylglycine, L-pyroglutamic acid, L-proline, 2-hydroxyethyl sulfonic acid, acetic acid, benzoic acid, glycine, lysine, arginine, aspartic acid, gallic acid, lactic acid, whey acid, malic acid, citric acid, methanesulfonic acid, benzenesulfonic acid and p-toluenesulfonicacid. The halodiazine salt provided by the invention takes hanfangchin B as a raw material, the halodiazine is prepared through bromination, methoxylation and methylation reactions, the reaction yieldis high, intermediates and products are easy to purify, and the halodiazine can be used for industrial preparation of the halodiazine salt.