66838-42-4

Basic information

• Product Name: (R)-Tetrahydro-3-furancarboxylic acid
• Synonyms: (R)-Tetrahydro-3-furancarboxylic acid;(R)-Tetrahydrofuran-3-carboxylic acid;(R)-Tetrahydrofuran-3-car...;(R)-Tetrahydro-3-furoic acid;(3R)-oxolane-3-carboxylic acid;3-Furancarboxylic acid, tetrahydro-, (3R)-;(R)-Tetrahydro-3-furoic acid >=97.0%;(3R)-Tetrahydrofuran-3-carboxylic acid
• CAS NO: 66838-42-4
• Molecular Formula: C₅H₈O₃
• Molecular Weight: 116.11522
• Product Categories: Heterocycle-other series
• Mol File: 66838-42-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 252.1°C at 760 mmHg
• Flash Point: 113.2°C
• Appearance: /
• Density: 1.262g/cm³
• Vapor Pressure: 0.00618mmHg at 25°C
• Refractive Index: 1.48
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.33±0.20(Predicted)
• BRN: 1281202
• CAS DataBase Reference: (R)-Tetrahydro-3-furancarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-Tetrahydro-3-furancarboxylic acid(66838-42-4)
• EPA Substance Registry System: (R)-Tetrahydro-3-furancarboxylic acid(66838-42-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 66838-42-4(Hazardous Substances Data)

Usage

Uses

(R)-Tetrahydrofuran-3-carboxylic Acid is used in preparation of the zeste enhancer homolog 2 inhibitor and their medical applications.

InChI:InChI=1/C5H8O3/c6-5(7)4-1-2-8-3-4/h4H,1-3H2,(H,6,7)/t4-/m1/s1

Upstream product

• 191347-92-9 (R)-tetrahydrofuran-3-carboxaldehyde 
• 1002728-73-5 2,5-dihydrofuran-3-carboxylic acid 
• 797038-33-6 tert-butyl 4-hydroxytetrahydrofuran-3-carboxylate 
• 797038-34-7 tert-butyl 2,5-dihydrofuran-3-carboxylate 
• 89364-31-8 3-tetrahydrofuroic acid 
• 1445651-64-8 tetrahydro-furan-3-carboxylic acid benzyl ester 
• 130193-89-4 (R)-tetrahydro-furan-3-carboxylic acid benzyl ester 

Downstream Products

• 1220514-58-8 C₂₇H₃₄FN₅O₃*ClH 
• 1220514-67-9 C₂₇H₃₄FN₅O₃ 
• 1163126-58-6 4-(2-fluoro-4-(((R)-tetrahydrofuran-3-carbonyl)amino)phenyl)piperazine-1-carboxylic acid tert-butyl ester 
• 124391-75-9 -(+)-3-hydroxymethyltetrahydrofuran 
• 165611-33-6 (R)-methyl tetrahydro-3-furoate 

Relevant articles and documents

Dihydro-Benzo-Oxazine and Dihydro-Pyrido-Oxazine Derivatives

The invention relates to dihydro-benzo-oxazine and dihydro-pyrido-oxazine compounds of the formula (I) and/or pharmaceutically acceptable salts and/or solvates thereof, wherein Y, V, W, U, Q, R1, R5, R7 and R30 are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.

Asymmetric Hydroformylation of Heterocyclic Olefins Catalyzed by Chiral Phosphine-Phosphite-Rh(I) Complexes

Asymmetric hydroformylation of heterocyclic olefins catalyzed by phosphine-phosphite-Rh(I) complexes has been investigated. Hydroformylation of symmetrical heterocyclic olefins such as 2,5-dihydrofuran, 3-pyrroline derivatives, and 4,7-dihydro-1,3-dioxepin derivatives afforded the optically active aldehydes as single products in 64-76% ee. Unsymmetrical substrates such as 2,3-dihydrofuran and N-(tert-butoxycarbonyl)-2-pyrroline gave a mixture of regioisomers. From N-(tert-butoxycarbonyl)-2-pyrroline was obtained N-(tert-butoxycarbonyl)pyrrolidine-2-carbaldehyde in 97% ee. The hydroformylation products from 2,5-dihydrofuran and N-(tert-butoxycarbonyl)-3-pyrroline have the opposite configurations to those from 2,3-dihydrofuran and N-(tert-butoxycarbonyl)-2-pyrroline, respectively, with the same catalyst. The new phosphine-phosphite ligand (R,S)-3,3′-Me2-BINAPHOS [= (A)-2-(diphenylphosphino)-1,1′-binaphthalen-2′-yl (S)-3,3′-dimethyl-1,1′-binaphthalene-2,2′-diyl phosphite] was prepared and its hydridorhodium complex was characterized by NMR spectroscopy. Using (R,S)-3,3′-Me2-BINAPHOS as a ligand, the enantioselectivity was improved for some substrates. In addition, higher catalytic activity was observed with this ligand for most of the substrates employed.