66873-47-0

Basic information

• Product Name: Acetic acid 4(S)-[(2R,4aR,6R,8aS)-6-[5(R)-bromo-2(S),6,6-trimethyltetrahydro-2H-pyran-2-yl]-8a-methyloctahydropyrano[3,2-b]pyran-2-yl}-4-hydroxy-1(S)-[5(R)-(1-hydroxy-1-methylethyl)-2(R)-methyltetrahydro-2-furanyl]pentyl ester
• Synonyms: Thyrsiferyl 18-acetate; TF-18A; 1(S)-Acetoxy-4(S)-[(2R,4aR,6R,8aS)-6-[5(R)-bromo-2(S),6,6-trimethyltetrahydro-2H-pyran-2-yl]-8a-methyloctahydropyrano[3,2-b]pyran-2-yl]-1-[5(R)-(1-hydroxy-1-methylethyl)-2(R)-methyltetrahydro-2-furanyl]-4-pentanol
• CAS NO: 66873-47-0
• Molecular Formula: C₃₂H₅₅BrO₈
• Molecular Weight: 647.69435
• Mol File: 66873-47-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Acetic acid 4(S)-[(2R,4aR,6R,8aS)-6-[5(R)-bromo-2(S),6,6-trimethyltetrahydro-2H-pyran-2-yl]-8a-methyloctahydropyrano[3,2-b]pyran-2-yl}-4-hydroxy-1(S)-[5(R)-(1-hydroxy-1-methylethyl)-2(R)-methyltetrahydro-2-furanyl]pentyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid 4(S)-[(2R,4aR,6R,8aS)-6-[5(R)-bromo-2(S),6,6-trimethyltetrahydro-2H-pyran-2-yl]-8a-methyloctahydropyrano[3,2-b]pyran-2-yl}-4-hydroxy-1(S)-[5(R)-(1-hydroxy-1-methylethyl)-2(R)-methyltetrahydro-2-furanyl]pentyl ester(66873-47-0)
• EPA Substance Registry System: Acetic acid 4(S)-[(2R,4aR,6R,8aS)-6-[5(R)-bromo-2(S),6,6-trimethyltetrahydro-2H-pyran-2-yl]-8a-methyloctahydropyrano[3,2-b]pyran-2-yl}-4-hydroxy-1(S)-[5(R)-(1-hydroxy-1-methylethyl)-2(R)-methyltetrahydro-2-furanyl]pentyl ester(66873-47-0)

Safety Data

• Hazardous Substances Data: 66873-47-0(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 93453-12-4 thyrsiferol 
• 304466-03-3 Acetic acid (S)-1-[(2R,5R)-5-(1-acetoxy-1-methyl-ethyl)-2-methyl-tetrahydro-furan-2-yl]-4-[(2R,4aR,6R,8aS)-6-((2S,5R)-5-bromo-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-8a-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-4-oxo-butyl ester 
• 304466-01-1 Acetic acid (E)-(S)-1-[(2R,5R)-5-(1-acetoxy-1-methyl-ethyl)-2-methyl-tetrahydro-furan-2-yl]-4-[(2R,4aR,6R,8aS)-6-((2S,5R)-5-bromo-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-8a-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-4-oxo-but-2-enyl ester 
• 304466-00-0 Acetic acid (E)-(S)-1-[(2R,5R)-5-(1-acetoxy-1-methyl-ethyl)-2-methyl-tetrahydro-furan-2-yl]-4-[(2R,4aR,6R,8aS)-6-((2S,5R)-5-bromo-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-8a-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-4-hydroxy-but-2-enyl ester 
• 240133-67-9 3-((2S,3R,6R)-6-Benzyloxymethyl-2-methyl-3-triethylsilanyloxy-tetrahydro-pyran-2-yl)-1-((2S,5R)-5-bromo-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-propynone 
• 240133-66-8 3-((2S,3R,6R)-6-Benzyloxymethyl-2-methyl-3-triethylsilanyloxy-tetrahydro-pyran-2-yl)-1-((2S,5R)-5-bromo-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-prop-2-yn-1-ol 
• 240133-56-6 ((2S,3R,6R)-6-Benzyloxymethyl-2-bromoethynyl-2-methyl-tetrahydro-pyran-3-yloxy)-triethyl-silane 
• 304465-93-8 1-((2S,5R)-5-Bromo-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-3-((2S,3R,6R)-3-hydroxy-6-hydroxymethyl-2-methyl-tetrahydro-pyran-2-yl)-propan-1-one 
• 304465-85-8 C₂₄H₂₇BrO₅ 
• 240133-63-5 {(R)-1-Benzyloxymethyl-3-[(2R,3R)-3-(2,2-dibromo-vinyl)-3-methyl-oxiranyl]-propoxy}-tert-butyl-dimethyl-silane 
• 240133-62-4 (E)-(R)-7-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-2-methyl-hept-2-enoic acid ethyl ester 
• 240133-54-4 [(2R,4aR,6R,8aS)-6-((2S,5R)-5-Bromo-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-8a-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-methanol 
• 240415-18-3 {(2R,3R)-3-[(R)-4-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-butyl]-2-methyl-oxiranyl}-methanol 

Relevant articles and documents

Total synthesis of thyrsiferyl 23-acetate, a specific inhibitor of protein phosphatase 2A and an anti-leukemic inducer of apoptosis

A convergent synthetic entry to the squalenoid polyether system has been developed and applied to the biologically active marine natural products thyrsiferyl 23-acetate (1a), thyrsiferol (1b), thyrsiferyl 18-acetate (1c), and thyrsiferyl 18,23-diacetate (

TERPENOIDS OF THE RED ALGA LAURENCIA PINNATIFIDA

The structures of three brominated terpenoids which are natural products from the red alga Laurencia pinnatifida (Gmal.Lamour) are described.The structures of the sesquiterpenes 4 and 5 were determined by spectral comparison and chemical interconversion.The structure of the squalene-derived terpenoid 8 was secured by chemical transformation into thyrsiferol, a brominated triterpene previously isolated from the red alga Laurencia thyrsifera.