66929-54-2

Basic information

• Product Name: 3-Buten-2-one, 1,1,1-trifluoro-4-hydroxy-4-phenyl-
• CAS NO: 66929-54-2
• Molecular Formula: C10H7F3O2
• Molecular Weight: 216.16
• Mol File: 66929-54-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-Buten-2-one, 1,1,1-trifluoro-4-hydroxy-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Buten-2-one, 1,1,1-trifluoro-4-hydroxy-4-phenyl-(66929-54-2)
• EPA Substance Registry System: 3-Buten-2-one, 1,1,1-trifluoro-4-hydroxy-4-phenyl-(66929-54-2)

Safety Data

• Hazardous Substances Data: 66929-54-2(Hazardous Substances Data)

Upstream product

• 3433-56-5 1-(1-phenylvinyl)pyrrolidine 
• 130240-22-1 (Z)-1,1,1-Trifluoro-4-phenyl-4-pyrrolidin-1-yl-but-3-en-2-one 
• 383-63-1 ethyl trifluoroacetate, 
• 98-86-2 acetophenone 

Downstream Products

• 883-93-2 2-Phenylbenzothiazole 
• 421-50-1 1,1,1-trifluoro-2-propanone 
• 870550-81-5 4,4,4-trifluoro-1-phenylbutane-1,2,3-trione 2-(1H-1,2,4-triazol-3-yl)hydrazone 
• 1151809-37-8 titanocene(trifluorobenzoylacetone^(1-))ClO₄ 
• 1020853-33-1 C₆H₅C(OH)CHC(CF₃)NC₆H₅ 
• 19269-15-9 Na(acacPhF₃) 

Relevant articles and documents

Synthesis and biological evaluation of salicylic acid analogues of celecoxib as a new class of selective cyclooxygenase-1 inhibitor

A series of salicylic acid analogues of celecoxib where the phenylsulfonamide moiety in the structure of celecoxib is replaced by salicylic acid moiety was synthesized and tested for in vitro cyclooxygenase (COX)-1 and COX-2 enzyme inhibition. Among the series, 5-substituted-2-hydroxy-benzoic acid analogues (7a–7h) generally showed better inhibitory activities on both enzymes than 4-substituted-2-hydroxy-ben-zoic acid analogues (12a–12h). In particular, the chloro analogue 7f which had the highest inhibitory effect (IC50=0.0057μM) to COX-1 with excellent COX-1 selectivity (SI=768) can be classified as a new potent and selective COX-1 inhibitor. The high inhibitory potency of 7f was rationalized through the docking simulation of this analogue in the active site of COX-1 enzyme.

4-Dimethylamino-1-trifluoroacetylpyridinium trifluoroacetate: An efficient reagent for the preparation of trifluoromethyl 1,3-dicarbonyl compounds

Enamines 2 and O-trimethylsilyl ketene acetals 4 are trifluoroacetylated on reaction with the title reagent to yield trifluoroacetyl enamines 3 and trifluoromethylsilylenol ethers 5, respectively. Trifluoromethyl 1,3-diketones 6 and trifluoromethyl β-keto esters 7 are obtained by hydrolysis of compounds 3 and 5.