66932-96-5

Basic information

• Product Name: 2-CHLORO-N-(3,5-DIMETHOXY-PHENYL)-ACETAMIDE
• Synonyms: 2-chloro-N-(3,5-dimethoxyphenyl)ethanamide;AKOS BBS-00003872;2-CHLORO-N-(3,5-DIMETHOXY-PHENYL)-ACETAMIDE;CHEMBRDG-BB 6638086;2-chloro-N-(3,5-dimethoxyphenyl)acetamide(SALTDATA: FREE)
• CAS NO: 66932-96-5
• Molecular Formula: C₁₀H₁₂ClNO₃
• Molecular Weight: 229.66
• Mol File: 66932-96-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 406.9°C at 760 mmHg
• Flash Point: 199.9°C
• Appearance: /
• Density: 1.262
• Vapor Pressure: 7.87E-07mmHg at 25°C
• Refractive Index: 1.558
• CAS DataBase Reference: 2-CHLORO-N-(3,5-DIMETHOXY-PHENYL)-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-N-(3,5-DIMETHOXY-PHENYL)-ACETAMIDE(66932-96-5)
• EPA Substance Registry System: 2-CHLORO-N-(3,5-DIMETHOXY-PHENYL)-ACETAMIDE(66932-96-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 66932-96-5(Hazardous Substances Data)

Usage

General Description

2-CHLORO-N-(3,5-DIMETHOXY-PHENYL)-ACETAMIDE, also known as 3,5-Dimethoxy-2-chloro-N-phenylacetamide, is a chemical compound with the molecular formula C10H12ClNO3. It is a derivative of acetamide and contains a chlorine atom and two methoxy groups attached to a phenyl ring. 2-CHLORO-N-(3,5-DIMETHOXY-PHENYL)-ACETAMIDE is commonly used in the pharmaceutical and research industries as a building block for the synthesis of various drugs and organic compounds. It has also been studied for its potential biological activities, including its antimicrobial and anti-inflammatory properties. Additionally, it has been investigated for its potential in the treatment of various diseases and conditions, making it a valuable and versatile chemical compound in the field of medicinal chemistry.

InChI:InChI=1/C10H12ClNO3/c1-14-8-3-7(12-10(13)6-11)4-9(5-8)15-2/h3-5H,6H2,1-2H3,(H,12,13)

Upstream product

• 630121-37-8 2-chloro-N-(3,5-dimethoxyphenyl)aniline 
• 79-04-9 chloroacetyl chloride 
• 10272-07-8 3.5-dimethoxyaniline 

Downstream Products

• 701259-52-1 N-(3,5-dimethoxyphenyl)-2-(4-nitrophenoxy)acetamide 
• 936632-74-5 1-deoxy-1-(6-{4-[(3,5-dimethoxyphenylcarbamoyl)methoxy]phenylamino}-9H-purin-9-yl)-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide 
• 936633-11-3 2-(4-aminophenoxy)-N-(3,5-dimethoxyphenyl)acetamide 

Relevant articles and documents

A convenient modified synthesis of 5-pyridinyl-1,3,4-thiadiazole-2-carboxamides

A general one-pot procedure is developed for the synthesis of 5-pyridinyl-1,3,4-thiadiazole-2-carboxamides by the reaction of pyridine carboxaldehydes with oxamic acid thiohydrazides. (Figure Presented).

N6-[(Hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5′-N-ethylcarboxamido-adenosines: The first example of adenosine-related structures with potent agonist activity at the human A2B adenosine receptor

A new series of N6-[(hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5′-N-ethylcarboxamido-adenosines (24-43) has been synthesised and tested in binding assays at hA1, hA2A and hA3 adenosine receptors, and in a functional assay at the hA2B subtype. The examined compounds displayed high potency in activating A2B receptors with good selectivity versus A2A subtypes. The introduction of an unsubstituted 4-[(phenylcarbamoyl)-methoxy]-phenyl chain at the N6 position of 5′-N-ethylcarboxamido-adenosine led us to the recognition of compound 24 as a full agonist displaying the highest efficacy of the series (EC50 hA2B = 7.3 nM). These compounds represent the first report about adenosine-related structures capable of activating hA2B subtype in the low nanomolar range.

Acetamides and benzamides that are useful in treating sexual dysfunction

The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.