66971-55-9

Basic information

• Product Name: 5-HYDRAZINO-1,3-DIMETHYL-4-NITRO-1H-PYRAZOLE
• Synonyms: 5-HYDRAZINO-1,3-DIMETHYL-4-NITRO-1H-PYRAZOLE;1,3-DIMETHYL-4-NITROPYRAZOLE-5-HYDRAZINE;5-hydrazinyl-1,3-dimethyl-4-nitro-1H-pyrazole
• CAS NO: 66971-55-9
• Molecular Formula: C₅H₉N₅O₂
• Molecular Weight: 171.16
• Mol File: 66971-55-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 179-180 °C(Solv: ethanol (64-17-5))
• Boiling Point: 338.5°C at 760 mmHg
• Flash Point: 158.5°C
• Appearance: /
• Density: 1.62g/cm³
• Vapor Pressure: 9.77E-05mmHg at 25°C
• Refractive Index: 1.692
• PKA: 4.26±0.70(Predicted)
• CAS DataBase Reference: 5-HYDRAZINO-1,3-DIMETHYL-4-NITRO-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-HYDRAZINO-1,3-DIMETHYL-4-NITRO-1H-PYRAZOLE(66971-55-9)
• EPA Substance Registry System: 5-HYDRAZINO-1,3-DIMETHYL-4-NITRO-1H-PYRAZOLE(66971-55-9)

Safety Data

• Hazardous Substances Data: 66971-55-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C5H9N5O2/c1-3-4(10(11)12)5(7-6)9(2)8-3/h7H,6H2,1-2H3

Upstream product

• 54454-10-3 5-chloro-1,3-dimethyl-pyrazole 
• 13551-73-0 5-chloro-1,3-dimethyl-4-nitro-1H-pyrazole 
• 76689-62-8 5-bromo-1,3-dimethyl-4-nitropyrazole 

Downstream Products

• 960502-50-5 N'-(1,3-dimethyl-4-nitro-1H-pyrazol-5-yl)-4-methylbenzohydrazide 
• 960502-53-8 N'-(1,3-dimethyl-4-nitro-1H-pyrazol-5-yl)-2-furohydrazide 
• 383396-18-7 N'-(1,3-dimethyl-4-nitro-1H-pyrazol-5-yl)benzohydrazide 
• 869300-88-9 5-[(1,3-dimethyl-4-nitro-1H-pyrazol-5-yl)hydrazono]-7,8-dimethoxy-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 
• 1217131-83-3 4-chlorobenzaldehyde (1,3-dimethyl-4-nitro-1H-pyrazol-5-yl)hydrazone 
• 304877-27-8 benzaldehyde (1,3-dimethyl-4-nitro-1H-pyrazol-5-yl)hydrazone 
• 300805-79-2 4-hydroxybenzaldehyde (1,3-dimethyl-4-nitro-1H-pyrazol-5-yl)hydrazone 
• 1217131-82-2 2,3-dimethoxybenzaldehyde (1,3-dimethyl-4-nitro-1H-pyrazol-5-yl)hydrazone 
• 3920-38-5 1,3-dimethyl-4-nitro-1H-pyrazole 
• 960502-54-9 N'-(4-amino-1,3-dimethyl-1H-pyrazol-5-yl)-4-methylbenzohydrazide 

Relevant articles and documents

Synthesis of 3- and 5-hydrazino-1-methyl-4-nitropyrazoles

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Synthesis, crystal structure, spectroscopic and computational studies of 2-{1-[2-(1,3-dimethyl-4-nitro-1H-pyrazol-5-yl)hydrazono]ethyl}pyridine

2-{1-[2-(1,3-Dimethyl-4-nitro-1H-pyrazol-5-yl)hydrazono]ethyl}-pyridine has been prepared from 5-hydrazino-1,3-dimethyl-4-nitro-1H-pyrazole and 2-acetylpyridine in an ethanolic solution. It crystallizes as an (E/Z) isomeric pair in the triclinic space group P-1 with the lattice parameters: a = 10.357(1) ?, b = 11.613(1) ?, c = 13.069(1) ?, α = 67.74(1)°, β = 70.77(1)°, γ = 67.92(1)°, volume = 1315.6(3) ?3, Z = 2. The isomeric pair (E/Z) is contained in the unit cell, where the N-H group is H-bonded to the pyridine nitrogen and to the oxygen of the nitro group in the Z-isomer and to the oxygen of the nitro group only in the E-isomer. NMR showed that the E-isomer is the major. DFT calculations were performed to further investigate the electronic properties of the synthesized compound.

5-Substituted derivatives of dipyrazolo[1,5-a:4',3'-e]pyrazine-6-carboxylic acids and esters

New 5-substituted derivatives of dipyrazolo[1,5-a:4',3'-e]pyrazine-6-carboxylic acid, esters and their salts have the formula STR1 R1 is hydrogen, lower alkyl or phenyl-lower alkylene; R2 and R3 each is hydrogen or lower alkyl; X is oxygen or sulfur; and R4 is hydrogen, lower alkyl, phenyl-lower alkylene or amino-lower alkylene. The new compounds are useful as anti-inflammatory agents and immunosuppressive agents.