67047-05-6Relevant articles and documents
Concise synthesis and antidiabetic activity of natural flavonoid glycosides, oroxins C and D, isolated from the seeds of Oroxylum indium
Li, Gang,Wang, Guanghui,Tong, Yangliu,Zhu, Junheng,Yun, Tongtong,Ye, Xiaoping,Li, Fahui,Yuan, Shengli,Liu, Qingchao
, p. 68 - 75 (2020/06/17)
The first concise synthesis of natural flavonoid glycosides, oroxins C (1) and D (2), which were isolated from the seeds of Oroxylum indicum, was efficiently achieved by a convergent strategy. The synthesized natural products 1 and 2 were evaluated for th
Baicalein active probe and synthetic method and application thereof
-
Paragraph 0045; 0052-0053, (2019/06/08)
The invention discloses a baicalein active probe, and provides a synthetic method and application of the baicalein active probe. The active probe uses baicalein as a reaction group, uses diethyleneimine as a photocrosslinking group, and uses alkynyl as a biologically orthogonal group. A structural formula is as follows: (Please see the specification for the formula). The baicalein active probe hasthe beneficial effects that (1) an anticancer mechanism based on a cell oxidative phosphorylation pathway is a novel anticancer mechanism, and is possible to achieve the effect of selectively killingcancer cells; (2) baicalein is the first discovered activator of the cell oxidative phosphorylation pathway; and (3) key proteins ATP4A(P20648), ATP5A1(P25705), ATP5F1(P24539), ATP5L(O75964), ATP6V1A(P38606), ATP6V1H(Q9UI12), ATP12A(P54707) and NDUFA13(Q9P0J0) in the cell oxidative phosphorylation pathway are targets for the development of novel anticancer drugs.
2-substituted benzopyran-4-one compounds and application thereof
-
Paragraph 0158; 0159; 0160, (2016/10/08)
The invention relates to the technical field of medicine and discloses 2-substituted benzopyran-4-one compounds with a structure shown in general formula I and an application of the compounds in preparation of antifungal drugs and synergistic antifungal drugs. The compounds can be jointly used with azole antifungal drugs, can improve sensibility of drug-resistance bacteria to the azole drugs, reverses drug resistance and produces a synergistic antifungal function.