6705-46-0

Basic information

• Product Name: Cyclopropyl propyl ketone
• Synonyms: Cyclopropyl propyl ketone;1-cyclopropyl-1-Butanone;1-cyclopropylbutan-1-one
• CAS NO: 6705-46-0
• Molecular Formula: C₇H₁₂O
• Molecular Weight: 112.17
• Mol File: 6705-46-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 154.1 °C at 760 mmHg
• Flash Point: 44.8 °C
• Appearance: /
• Density: 0.954 g/cm³
• Vapor Pressure: 3.23mmHg at 25°C
• Refractive Index: 1.462
• CAS DataBase Reference: Cyclopropyl propyl ketone(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropyl propyl ketone(6705-46-0)
• EPA Substance Registry System: Cyclopropyl propyl ketone(6705-46-0)

Safety Data

• Hazardous Substances Data: 6705-46-0(Hazardous Substances Data)

Usage

General Description

Cyclopropyl propyl ketone is a chemical compound with the molecular formula C6H10O. It is also known as ethylcyclopropane. Cyclopropyl propyl ketone is a colorless liquid with a pungent odor, commonly used as a flavoring agent in the food industry, and as a fragrance additive in the perfume industry. It is also utilized in organic synthesis as a building block for the preparation of various pharmaceutical compounds. Additionally, cyclopropyl propyl ketone is known to have moderate acute toxicity, and exposure to high concentrations can cause irritation to the eyes, skin, and respiratory system. Therefore, proper handling and safety precautions should be taken when working with this chemical.

InChI:InChI=1/C7H12O/c1-2-3-7(8)6-4-5-6/h6H,2-5H2,1H3

Upstream product

• 59533-51-6 1-chloro-4-heptanone 
• 24230-08-8 2-Cyclopropyl-pentanol-(2) 
• 930-57-4 n-butylcyclopropane 
• 5500-21-0 cyclopropropanecarbonitrile 
• 24767-75-7 toluene-4-sulfonic acid hepta-3,4-dienyl ester 
• 927-77-5 n-propylmagnesium bromide 
• 4023-34-1 cyclopropanecarboxylic acid chloride 
• 5457-40-9 2-cyclopropyl-pent-1-ene 
• 1121-37-5 dicyclopropyl ketone 

Downstream Products

• 24230-08-8 2-Cyclopropyl-pentanol-(2) 
• 1576-77-8 1-acetoxy-hept-3t-ene 
• 2108-05-6 trans-3-hepten-1-ol 

Relevant articles and documents

Oxyfunctionalization of non-natural targets by dioxiranes. 5. Selective oxidation of hydrocarbons bearing cyclopropyl moieties

The powerful methyl(trifluoromethyl)dioxirane (lb) was employed to achieve the direct oxyfunctionalization of 2,4-didehydroadamantane (5), spiro[cyclopropane-1,2′-adamantane] (9), spiro[2.5]-octane (17), and bicyclo[6.1.0]nonane (19). The results are compared with those attained in the analogous oxidation of two alkylcyclopropanes, i.e., n-butylcyclopropane (11) and (3-methyl-butyl)-cyclopropane (14). The product distributions observed for 11 and 14 show that cyclopropyl activation of α-C-H bonds largely prevails when no tertiary C-H are present in the open chain in the tether; however, in the oxyfunctionalixation of 14 cyclopropyl activation competes only mildly with hydroxylation at the tertiary C-H. The application of dioxirane 1b to polycyclic alkanes possessing a sufficiently rigid framework (such as 5 and 9) demonstrates the relevance of relative orientation of the cyclopropane moiety with respect to the proximal C-H undergoing oxidation. At one extreme, as observed in the oxidation of rigid spiro compound 9, even bridgehead tertiary C-H's become deactivated by the proximal cyclopropyl moiety laying in the unfavorable eclipsed (perpendicular) orientation; at the other end, a cyclopropane moiety constrained in a favorable bisected orientation (as for didehydroadamantane 5) can activate an α methylene CH2 to compete effectively with dioxirane O-insertion into tertiary C-H bonds. Comparison with literature reports describing similar oxidations by dimethyldioxirane (1a) demonstrate that methyl(trifluoromethyl)dioxirane (1b) presents similar selectivity and remarkably superior reactivity.

Synthesis and Antimalarial Activity of 8--6-methoxy-4-methylquinolines

Three analogues of the causal prophylactic antimalarial primaquine were prepared and their antimalarial activity was evaluated. 8--6-methoxy-4-methylquinoline (2a) demonstrated activity against Plasmodium berghei in mice at 20 mg/kg, with all animals cured at 320 mg/kg, and is without toxicity at 640 mg/kg.It also possessed outstanding causal prophylactic activity against Plasmodium cynomolgi in rhesus monkeys at very low dosages.