671215-62-6

Basic information

• Product Name: 1-PHENYLSULFONYLINDOLE-5-ALDEHYDE
• Synonyms: 1-PHENYLSULFONYLINDOLE-5-CARBOXALDEHYDE;1-PHENYLSULFONYLINDOLE-5-ALDEHYDE;1-(Benzenesulfonyl)-1H-indole-5-carbaldehyde
• CAS NO: 671215-62-6
• Molecular Formula: C₁₅H₁₁NO₃S
• Molecular Weight: 285.32
• Mol File: 671215-62-6.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-PHENYLSULFONYLINDOLE-5-ALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENYLSULFONYLINDOLE-5-ALDEHYDE(671215-62-6)
• EPA Substance Registry System: 1-PHENYLSULFONYLINDOLE-5-ALDEHYDE(671215-62-6)

Safety Data

• Hazardous Substances Data: 671215-62-6(Hazardous Substances Data)

Usage

Description

1-Phenylsulfonylindole-5-aldehyde is a chemical compound that belongs to the class of indole-5-aldehydes. It contains a phenylsulfonyl group attached to the indole ring, as well as an aldehyde functional group. 1-PHENYLSULFONYLINDOLE-5-ALDEHYDE has potential applications in various fields due to its unique structure and functional groups.

Uses

Used in Organic Synthesis:
1-Phenylsulfonylindole-5-aldehyde is used as a key intermediate in the construction of complex indole-derived molecules. Its presence of both phenylsulfonyl and aldehyde functional groups allows for versatile synthetic transformations, making it a valuable building block in organic synthesis.
Used in Pharmaceutical Industry:
1-Phenylsulfonylindole-5-aldehyde is used as a key intermediate in the preparation of various pharmaceuticals. Its unique structure and functional groups can be utilized in the development of new drugs and bioactive compounds, particularly in medicinal chemistry.
Used in Agrochemical Industry:
1-Phenylsulfonylindole-5-aldehyde is also used in the agrochemical industry for the preparation of various agrochemicals. Its potential applications in this field can contribute to the development of new and effective agrochemical products.
Used in Fine Chemicals Industry:
1-Phenylsulfonylindole-5-aldehyde is used as a key intermediate in the production of other fine chemicals. Its unique structure and functional groups make it a valuable component in the synthesis of specialty chemicals for various applications.

Upstream product

• 10075-50-0 5-bromo-1H-indole 
• 1196-69-6 1H-indole-5-carboxaldehyde 
• 98-09-9 benzenesulfonyl chloride 

Relevant articles and documents

Expedient Synthesis of Bridged Bicyclic Nitrogen Scaffolds via Orthogonal Tandem Catalysis

Bridged nitrogen bicyclic skeletons have been accessed via unprecedented site- and diastereoselective orthogonal tandem catalysis from readily accessible reactants in a step economic manner. Directed Pd-catalyzed γ-C(sp3)-H olefination of aminocyclohexane with gem-dibromoalkenes, followed by a consecutive intramolecular Cu-catalyzed amidation of the 1-bromo-1-alkenylated product delivers the interesting normorphan skeleton. The tandem protocol can be applied on substituted aminocyclohexanes and aminoheterocycles, easily providing access to the corresponding substituted, aza- and oxa-analogues. The Cu catalyst of the Ullmann-Goldberg reaction additionally avoids off-cycle Pd catalyst scavenging by alkenylated reaction product. The picolinamide directing group stabilizes the enamine of the 7-alkylidenenormorphan, allowing further product post functionalizations. Without Cu catalyst, regio- and diastereoselective Pd-catalyzed γ-C(sp3)-H olefination is achieved.

METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

MAP4K4 (HGK) Inhibitors

The invention provides mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) inhibitors, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant diminution of tumor cell growth, cancer or metastasis.