67159-84-6

Basic information

• Product Name: 6-BroMo-3,3-diMethyl-2,3-dihydro-1H-inden-1-one
• Synonyms: 6-BroMo-3,3-diMethyl-2,3-dihydro-1H-inden-1-one;6-bromo-2,3-dihydro-3,3-dimethyl-1H-inden-1-one;6-Bromo-3,3-dimethyl-indan-1-one
• CAS NO: 67159-84-6
• Molecular Formula: C₁₁H₁₁BrO
• Molecular Weight: 239.10844
• Mol File: 67159-84-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 117-119 °C(Solv: ethanol (64-17-5))
• Boiling Point: 304.7±41.0 °C(Predicted)
• Appearance: /
• Density: 1.409±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 6-BroMo-3,3-diMethyl-2,3-dihydro-1H-inden-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BroMo-3,3-diMethyl-2,3-dihydro-1H-inden-1-one(67159-84-6)
• EPA Substance Registry System: 6-BroMo-3,3-diMethyl-2,3-dihydro-1H-inden-1-one(67159-84-6)

Safety Data

• Hazardous Substances Data: 67159-84-6(Hazardous Substances Data)

Usage

General Description

6-Bromo-3,3-dimethyl-2,3-dihydro-1H-inden-1-one is a synthetic chemical compound. It is an aromatic ketone with a bromine atom by the indene ring. The presence of bromine makes this compound highly reactive, making it useful in a variety of chemical reactions. The two methyl groups attached to the indene ring increase its lipophilicity, potentially influencing its interactivity with biological molecules. It’s mainly used as an intermediate in organic synthesis. Its IUPAC name is 6-bromo-3,3-dimethyl-2,3-dihydro-1H-inden-1-one. Although the exact toxicity of this compound is not widely reported, general precautions should be taken while handling it due to its reactivity.

Upstream product

• 67159-81-3 5-Amino-1,1-dimethyl-indan-3-one 
• 26465-81-6 3,3-dimethylindan-1-one 
• 638-10-8 ethyl 3-methylbut-2-enoate 
• 5467-74-3 4-Bromophenylboronic acid 
• 108-86-1 bromobenzene 
• 541-47-9 3-Methylbutenoic acid 
• 67159-79-9 3,3-dimethyl-6-nitro-indan-1-one 

Downstream Products

• 166978-72-9 methyl 4-[2-(1,1-dimethyl-3-oxo-indan-5-yl)vinyl]benzoate 
• 166978-63-8 methyl 1,1-dimethyl-3-phenyl-1H-indene-5-carboxylate 

Relevant articles and documents

Synthesis of β,β-disubstituted indanones via the Pd-catalyzed tandem conjugate addition/cyclization reaction of arylboronic acids with α,β-unsaturated esters

Under Pd catalysis with a newly synthesized electron-deficient heterocycle, 2-(4,5-dihydroimidazol-2-yl)- pyrimidine (as the ligand), the reaction of α,β-unsaturated esters with arylboronic acids afforded a wide range of 3,3-disubstituted indan-1-ones bearing a quaternary carbon in high yields. Mechanistic studies revealed that the reaction involves a tandem conjugate addition/1,4-Pd shift followed by a cyclization.

Substituted Spiro-amide Compounds

Substituted spiro-amide compounds corresponding to formula I in which R5 through R8, D, X, Y and Z have defined meanings, processes for preparing such spiro-amide compounds, pharmaceutical compositions containing such compounds, and methods of using such spiro-amide compounds for treating and/or inhibiting disorders or disease states mediated at least in part by the bradykinin 1 receptor.

Retinoid-like compounds

The present invention relates to a compound of formula STR1 or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in which X is --O--CO--, --NH--CO--, --CS--NH--, --CO--O--, --CO--NH--, --COS--, --SCO--, --SCH2 --, --CH2 --CH2 --, --C C--, --CH2 --NH--, --COCH2 --, --NHCS--, --CH2 S--, --CH2 O--, --OCH2 --, --NHCH2 -- or --CR5 =CR6 --; Rm and Rk are independently hydrogen, halogen, C1-6 alkyl, hydroxy, C1-6 alkyloxy or nitro; n is zero or one; R4 is --(CH2)t --Y, C1-6 alkyl, or C3-6 cycloalkyl; R1 is --CO2 Z, C1-6 alkyl, CH2 OH, --CONHRy, or CHO; R2 and R3 are independently hydrogen or C1-6 alkyl; Ra and Rb are independently hydrogen or C1-6 alkyl; but when n is one, Ra and Rb together can form a radical of the formula STR2 Y is naphthyl or phenyl, both radicals can be optionally substituted with one to three same or different C1-6 alkyl or halogen; Z is hydrogen or C1-6 alkyl; R5, R6 and Ry are independently hydrogen or C1-6 alkyl; and t is zero to six.